Impact of mechanical stretch on the cell behaviors of bone and surrounding tissues


Mechanical loading is recognized to play an important role in regulating the behaviors of cells in bone and surrounding tissues in vivo. Many in vitro studies have been conducted to determine the effects of mechanical loading on individual cell types of the tissues. In this review, we focus specifically on the use of the Flexercell system as a tool for studying cellular responses to mechanical stretch. We assess the literature describing the impact of mechanical stretch on different cell types from bone, muscle, tendon, ligament, and cartilage, describing individual cell phenotype responses. In addition, we review evidence regarding the mechanotransduction pathways that are activated to potentiate these phenotype responses in different cell populations.

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Divisions: College of Health & Life Sciences > School of Biosciences
College of Health & Life Sciences
Additional Information: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License ( which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (
Publication ISSN: 2041-7314
Last Modified: 17 Jun 2024 07:43
Date Deposited: 30 Jul 2019 14:01
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Related URLs: https://journal ... 041731415618342 (Publisher URL)
PURE Output Type: Review article
Published Date: 2016-03-16
Accepted Date: 2015-10-15
Authors: Yu, Hye-Sun
Kim, Jung-Ju
Kim, Hae-Won
Lewis, Mark P
Wall, Ivan (ORCID Profile 0000-0001-6294-8348)


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