Prototype of an opto-capacitive probe for non-invasive sensing cerebrospinal fluid circulation

Abstract

In brain studies, the function of the cerebrospinal fluid (CSF) awakes growing interest, particularly related to studies of the glymphatic system in the brain, which is connected with the complex system of lymphatic vessels responsible for cleaning the tissues. The CSF is a clear, colourless liquid including water (H2O) approximately with a concentration of 99 %. In addition, it contains electrolytes, amino acids, glucose, and other small molecules found in plasma. The CSF acts as a cushion behind the skull, providing basic mechanical as well as immunological protection to the brain. Disturbances of the CSF circulation have been linked to several brain related medical disorders, such as dementia. Our goal is to develop an in vivo method for the non-invasive measurement of cerebral blood flow and CSF circulation by exploiting optical and capacitive sensing techniques simultaneously. We introduce a prototype of a wearable probe that is aimed to be used for long-term brain monitoring purposes, especially focusing on studies of the glymphatic system. In this method, changes in cerebral blood flow, particularly oxy- and deoxyhaemoglobin, are measured simultaneously and analysed with the response gathered by the capacitive sensor in order to distinct the dynamics of the CSF circulation behind the skull. Presented prototype probe is tested by measuring liquid flows inside phantoms mimicking the CSF circulation.

Publication DOI: https://doi.org/10.1117/12.2251977
Divisions: College of Engineering & Physical Sciences > School of Engineering and Technology > Mechanical, Biomedical & Design
College of Engineering & Physical Sciences
Additional Information: Copyright 2017 SPIE. One print or electronic copy may be made for personal use only. Systematic reproduction, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.
Uncontrolled Keywords: brain,capacitive sensing,cerebrospinal fluid,optical methods,opto-capacitive probe,Electronic, Optical and Magnetic Materials,Atomic and Molecular Physics, and Optics,Biomaterials,Radiology Nuclear Medicine and imaging
Publication ISSN: 1996-756X
Full Text Link:
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
https://www.spi ... 12.2251977.full (Publisher URL)
PURE Output Type: Conference article
Published Date: 2017-03-03
Accepted Date: 2017-01-01
Authors: Myllylä, Teemu
Vihriälä, Erkki
Pedone, Matteo
Korhonen, Vesa
Surazynski, Lukasz
Wróbel, Maciej
Zienkiewicz, Aleksandra
Hakala, Jaakko
Sorvoja, Hannu
Lauri, Janne
Fabritius, Tapio
Jȩdrzejewska-Szczerska, Małgorzata
Kiviniemi, Vesa
Meglinski, Igor (ORCID Profile 0000-0002-7613-8191)

Download

[img]

Version: Published Version

| Preview

Export / Share Citation


Statistics

Additional statistics for this record