Analysis of skin blood microflow oscillations in patients with rheumatic diseases


Laser Doppler flowmetry (LDF) has been applied for the assessment of variation in blood microflows in patients with rheumatic diseases and healthy volunteers. Oscillations of peripheral blood microcirculation observed by LDF have been analyzed utilizing a wavelet transform. A higher amplitude of blood microflow oscillations has been observed in a high frequency band (over 0.1 Hz) in patients with rheumatic diseases. Oscillations in the high frequency band decreased in healthy volunteers in response to the cold pressor test, whereas lower frequency pulsations prevailed in patients with rheumatic diseases. A higher perfusion rate at normal conditions was observed in patients, and a weaker response to cold stimulation was observed in healthy volunteers. Analysis of blood microflow oscillations has a high potential for evaluation of mechanisms of blood flow regulation and diagnosis of vascular abnormalities associated with rheumatic diseases.

Publication DOI:
Divisions: College of Engineering & Physical Sciences > School of Engineering and Technology > Mechanical, Biomedical & Design
College of Engineering & Physical Sciences
Additional Information: © 2017 Society of Photo-Optical Instrumentation Engineers (SPIE)
Uncontrolled Keywords: blood microflows,laser Doppler flowmetry,oscillations,peripheral blood circulation,rheumatic,wavelet transfer,Electronic, Optical and Magnetic Materials,Biomaterials,Atomic and Molecular Physics, and Optics,Biomedical Engineering
Publication ISSN: 1560-2281
Full Text Link:
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
https://www.spi ... 2.7.070501.full (Publisher URL)
PURE Output Type: Article
Published Date: 2017-07-13
Accepted Date: 2017-06-21
Authors: Mizeva, Irina
Makovik, Irina
Dunaev, Andrey
Krupatkin, Alexander
Meglinski, Igor (ORCID Profile 0000-0002-7613-8191)



Version: Published Version

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