Submicron scale tissue multifractal anisotropy in polarized laser light scattering

Abstract

The spatial fluctuations of the refractive index within biological tissues exhibit multifractal anisotropy, leaving its signature as a spectral linear diattenuation of scattered polarized light. The multifractal anisotropy has been quantitatively assessed by the processing of relevant Mueller matrix elements in the Fourier domain, utilizing the Born approximation and subsequent multifractal analysis. The differential scaling exponent and width of the singularity spectrum appear to be highly sensitive to the structural multifractal anisotropy at the micron/sub-micron length scales. An immediate practical use of these multifractal anisotropy parameters was explored for non-invasive screening of cervical precancerous alterations ex vivo, with the indication of a strong potential for clinical diagnostic purposes.

Publication DOI: https://doi.org/10.1088/1612-202X/aa86f2
Divisions: College of Engineering & Physical Sciences > School of Engineering and Technology > Mechanical, Biomedical & Design
College of Engineering & Physical Sciences
Additional Information: ©2018 IOP Publishing Ltd.
Uncontrolled Keywords: other optical properties,polarization,scattering,spectroscopy,tissue characterization,tissue diagnostics,Instrumentation,Physics and Astronomy (miscellaneous)
Publication ISSN: 1612-202X
Full Text Link:
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
https://iopscie ... 612-202X/aa86f2 (Publisher URL)
PURE Output Type: Article
Published Date: 2018-02-01
Accepted Date: 2017-08-11
Authors: Das, Nandan Kumar
Dey, Rajib
Chakraborty, Semanti
Panigrahi, Prasanta K.
Meglinski, Igor (ORCID Profile 0000-0002-7613-8191)
Ghosh, Nirmalya

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