3D Mueller-matrix diffusive tomography of polycrystalline blood films for cancer diagnosis

Abstract

The decomposition of the Mueller matrix of blood films has been carried out using differential matrices with polarized and depolarized parts. The use of a coherent reference wave is applied and the algorithm of digital holographic reconstruction of the field of complex amplitudes is used. On this basis, the 3D Mueller-matrix diffuse tomography method-the reconstruction of distributions of fluctuations of linear and circular birefringence of depolarizing polycrystalline films of human blood is analytically justified and experimentally tested. The dynamics of the change in the magnitude of the statistical moments of the first-fourth order, which characterize layer-by-layer distributions of fluctuations in the phase anisotropy of the blood film, is examined and analyzed. The most sensitive parameters for prostate cancer are the statistical moments of the third and fourth orders, which characterize the asymmetry and kurtosis of fluctuations in the linear and circular birefringence of blood films. The excellent accuracy of differentiation obtained polycrystalline films of blood from healthy donors and patients with cancer patients was achieved.

Publication DOI: https://doi.org/10.3390/photonics5040054
Divisions: College of Engineering & Physical Sciences > School of Engineering and Technology > Mechanical, Biomedical & Design
College of Engineering & Physical Sciences
Additional Information: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
Uncontrolled Keywords: Blood,Cancer diagnostics,Mueller-matrix,Polarimetry,Polarization,Atomic and Molecular Physics, and Optics,Instrumentation,Radiology Nuclear Medicine and imaging
Publication ISSN: 2304-6732
Full Text Link:
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
https://www.mdp ... 304-6732/5/4/54 (Publisher URL)
PURE Output Type: Article
Published Date: 2018-12-01
Accepted Date: 2018-11-23
Authors: Ushenko, Volodimir
Sdobnov, Anton
Syvokorovskaya, Anna
Dubolazov, Alexander
Vanchulyak, Oleh
Ushenko, Alexander
Ushenko, Yurii
Gorsky, Mykhailo
Sidor, Maxim
Bykov, Alexander
Meglinski, Igor (ORCID Profile 0000-0002-7613-8191)

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