Diagnosis and Management of Non-IgE gastrointestinal Allergies in Breastfed Infants - an EAACI Position Paper


It is well-established that food proteins, such as egg, soya, cow's milk and wheat, are detectable in breastmilk for many hours or days after ingestion. Exposure to these proteins is important to the process of developing tolerance but can also sometimes elicit IgE-mediated and non-IgE-mediated allergic symptoms in breastfed infants. Non-IgE-mediated allergy, outside of food protein-induced allergic proctocolitis and eosinophilic oesophagitis, is not well understood, leading to variations in the diagnosis and management thereof. A primary objective of the European Academy for Allergy and Clinical Immunology is to support breastfeeding in all infants, including those with food allergies. A Task Force was established, to explore the clinical spectrum of non-IgE-mediated allergies, and part of its objectives was to establish diagnosis and management of non-IgE-mediated allergies in breastfed infants. Eight questions were formulated using the Patient, Intervention, Comparison, Outcome (PICO) system and Scottish Intercollegiate Guideline Network (SIGN) criteria for data inclusion, and consensus was achieved on practice points through the Delphi method. This publication aims to provide a comprehensive overview on this topic with practice points for healthcare professionals.

Publication DOI: https://doi.org/10.1111/all.13947
Divisions: College of Health & Life Sciences > School of Psychology
College of Health & Life Sciences
Additional Information: This is the peer reviewed version of the following article: Meyer, R. , Chebar Lozinsky, A. , Fleischer, D. M., Vieira, M. C., Du Toit, G. , Vandenplas, Y. , Dupont, C. , Knibb, R. , Uysal, P. , Cavkaytar, O. , Nowak‐Wegrzyn, A. , Shah, N. and Venter, C. (2019), Diagnosis and Management of Non‐IgE gastrointestinal Allergies in Breastfed Infants – an EAACI Position Paper. Allergy. Accepted Author Manuscript, which has been published in final form at https://doi.org/10.1111/all.13947.  This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
Uncontrolled Keywords: breastfed children,diagnosis of non–IgE-mediated allergy,food allergy,maternal elimination,non–IgE-mediated allergy,Immunology and Allergy,Immunology
Publication ISSN: 1398-9995
Last Modified: 29 Feb 2024 08:16
Date Deposited: 24 Jun 2019 08:08
Full Text Link:
Related URLs: https://onlinel ... .1111/all.13947 (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2020-01-01
Published Online Date: 2019-06-14
Accepted Date: 2019-06-14
Authors: Meyer, Rosan
Chebar Lozinsky, Adriana
Fleischer, David M
Vieira, Mario C
Du Toit, George
Vandenplas, Yvan
Dupont, Christophe
Knibb, Rebecca (ORCID Profile 0000-0001-5561-0904)
Uysal, Piınar
Cavkaytar, Ozlem
Nowak-Wegrzyn, Anna
Shah, Neil
Venter, Carina



Version: Accepted Version

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