Birthweight, HIV exposure and infant feeding as predictors of malnutrition in Botswanan infants

Abstract

Background: A better understanding of the nutritional status of infants who are HIV-Exposed-Uninfected (HEU) and HIV-Unexposed-Uninfected (HUU) during their first 1000 days is key to improving population health, particularly in sub-Saharan Africa. Methods: A cross-sectional study compared the nutritional status, feeding practices and determinants of nutritional status of HEU and HUU infants residing in representative selected districts in Botswana during their first 1000 days of life. Four hundred and thirteen infants (37.3% HIV-exposed), aged 6–24 months, attending routine child health clinics, were recruited. Anthropometric, 24-h dietary intake and socio-demographic data was collected. Anthropometric Z-scores were calculated using 2006 World Health Organization growth standards. Modelling of the determinants of malnutrition was undertaken using logistic regression. Results: Overall, the prevalences of stunting, wasting and being underweight were 10.4%, 11.9% and 10.2%, respectively. HEU infants were more likely to be underweight (15.6% versus 6.9%), (P < 0.01) and stunted (15.6% versus 7.3%), (P < 0.05) but not wasted (P = 0.14) than HUU infants. HEU infants tended to be formula fed (82.5%), whereas HUU infants tended to breastfeed (94%) for the first 6 months (P < 0.001). Significant predictors of nutritional status were HIV exposure, birthweight, birth length, APGAR (appearance, pulse, grimace, activity and respiration) score and mother/caregiver's education with little influence of socio-economic status. Conclusions: HEU infants aged 6–24 months had worse nutritional status compared to HUU infants. Low birthweight was the main predictor of undernutrition in this population. Optimisation of infant nutritional status should focus on improving birthweight. In addition, specific interventions should target HEU infants aiming to eliminate growth disparity between HEU and HUU infants.

Publication DOI: https://doi.org/10.1111/jhn.12517
Divisions: College of Health & Life Sciences > Aston Medical School
Funding Information: We gratefully acknowledge the participants for their willingness to engage in this research. We thank the Government of Botswana via the Botswana International University of Science and Technology (BIUST) for funding the PhD studies of PC. The University
Additional Information: This is the peer reviewed version of the following article: Chalashika, P., Essex, C., Duane, M., Swift, J.A. & Langley‐Evans, S. ( 2017) Birthweight, HIV exposure and infant feeding as predictors of malnutrition in Botswanan infants. J Hum Nutr Diet. 30, 779– 790, which has been published in final form at https://doi.org/10.1111/jhn.12517.  This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
Uncontrolled Keywords: 1000 days,Botswana,child undernutrition,HIV,infant feeding practices,malnutrition,Medicine (miscellaneous),Nutrition and Dietetics
Publication ISSN: 0952-3871
Last Modified: 29 Apr 2024 07:31
Date Deposited: 18 Jun 2019 14:11
Full Text Link: http://eprints. ... am.ac.uk/45358/
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
https://onlinel ... .1111/jhn.12517 (Publisher URL)
PURE Output Type: Article
Published Date: 2017-12-01
Published Online Date: 2017-09-28
Accepted Date: 2017-09-01
Authors: Chalashika, P.
Essex, C.
Mellor, D. (ORCID Profile 0000-0002-1369-3868)
Swift, J. A.
Langley-Evans, S.

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