Evaluation of dietary and lifestyle changes as modifiers of S100β levels in Alzheimer's disease


There is a significant body of research undertaken in order to elucidate the mechanisms underlying the pathology of Alzheimer's disease (AD), as well as to discover early detection biomarkers and potential therapeutic strategies. One such proposed biomarker is the calcium binding protein S100β, which, depending on its local concentration, is known to exhibit both neurotrophic and neuroinflammatory properties in the central nervous system. At present, relatively little is known regarding the effect of chronic S100β disruption in AD. Dietary intake has been identified as a modifiable risk factor for AD. Preliminary in vitro and animal studies have demonstrated an association between S100β expression and dietary intake which links to AD pathophysiology. This review describes the association of S100β to fatty acids, ketone bodies, insulin, and botanicals as well as the potential impact of physical activity as a lifestyle factor. We also discuss the prospective implications of these findings, including support of the use of a Mediterranean dietary pattern and/or the ketogenic diet as an approach to modify AD risk. Publisher Statement: This is an Accepted Manuscript of an article published by Taylor & Francis in Nutritional Neuroscience on 11th July 2017, available online: http://www.tandfonline.com/10.1080/1028415X.2017.1349032

Publication DOI: https://doi.org/10.1080/1028415X.2017.1349032
Divisions: College of Health & Life Sciences > Aston Medical School
Additional Information: This is an Accepted Manuscript of an article published by Taylor & Francis Group in Nutritional Neuroscience on 11 July 2017, available online at: http://www.tandfonline.com/10.1080/1028415X.2017.1349032
Publication ISSN: 1476-8305
Last Modified: 13 May 2024 07:25
Date Deposited: 18 Jun 2019 13:38
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Related URLs: https://www.tan ... rnalCode=ynns20 (Publisher URL)
PURE Output Type: Review article
Published Date: 2019-01-02
Published Online Date: 2017-07-11
Accepted Date: 2017-07-01
Authors: D'Cunha, Nathan
McKune, Andrew
Panagiotakos, Demosthenes
Georgouspoulou, Ekavi
Thomas, Jackson
Mellor, Duane (ORCID Profile 0000-0002-1369-3868)
Naumovski, Nenad



Version: Accepted Version

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