Tocotrienols, health and ageing: A systematic review

Abstract

Objectives A systematic review of studies was undertaken to evaluate the potential effect of intake of tocotrienols or circulating levels of tocotrienols on parameters associated with successful ageing, specifically in relation to cognitive function, osteoporosis and DNA damage. Methods Following PRISMA guidelines a systematic review of epidemiological observational studies and clinical trials was undertaken. Inclusion criteria included all English language publications in the databases PubMed and Scopus, through to the end of July 2016. Results Evidence from prospective and case-control studies suggested that increased blood levels of tocotrienols were associated with favorable cognitive function outcomes. A clinical trial of tocotrienol supplementation for 6 months suggested a beneficial effect of intake on DNA damage rates, but only in elderly people. Regarding osteoporosis, only in vitro studies with cultures of human bone cells were identified, and these demonstrated significant inhibition of osteoclast activity and promotion of osteoblast activity. Conclusions Research in middle-aged and elderly humans suggests that tocotrienols have a potential beneficial anti-ageing action with respect to cognitive impairment and DNA damage. Clinical trials are required to elucidate these effects.

Publication DOI: https://doi.org/10.1016/j.maturitas.2016.11.003
Divisions: College of Health & Life Sciences > Aston Medical School
Additional Information: © 2016, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Publication ISSN: 1873-4111
Last Modified: 01 Apr 2024 07:33
Date Deposited: 18 Jun 2019 07:35
Full Text Link:
Related URLs: https://www.sci ... 2638?via%3Dihub (Publisher URL)
PURE Output Type: Review article
Published Date: 2017-01-01
Published Online Date: 2016-11-09
Accepted Date: 2016-11-04
Authors: Georgousopoulou, Ekavi N.
Panagiotakos, Demosthenes B.
Mellor, Duane D. (ORCID Profile 0000-0002-1369-3868)
Naumovski, Nenad

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