H3PW12O40/SBA-15 for the Solventless Synthesis of 3-Substituted Indoles

Abstract

A family of silica-supported H3PW12O40 (HPW) solid acid catalysts was prepared by wet impregnation of mesoporous SBA-15 and investigated for the solventless synthesis of 3-substituted indoles under mild conditions. Mesoporous SBA-15 facilitated a high dispersion of immobilised H3PW12O40, significantly improving the catalytic efficiency of the heteropolyacid for the desired multi-component transformation. The yield of 3-substituted indoles strongly correlated with HPW loading (which spanned 3.2–51.6 wt %) and corresponding acid strength; the 51.6 wt % HPW/SBA-15 delivered 81% yield of 2-[(1H-indol-3-yl)(phenyl)methyl]malononitrile, approximately five times greater than that of the unsupported HPW, and exhibited a broad substrate scope for aromatic aldehydes.

Publication DOI: https://doi.org/10.3390/catal9050409
Divisions: College of Engineering & Physical Sciences > School of Infrastructure and Sustainable Engineering > Chemical Engineering & Applied Chemistry
Additional Information: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
Uncontrolled Keywords: 3-substituted indole,Condensation,H PW O,SBA-15,Catalysis,Physical and Theoretical Chemistry
Full Text Link:
Related URLs: https://www.mdp ... 73-4344/9/5/409 (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2019-04-30
Accepted Date: 2019-04-15
Authors: Tayebee, Reza
Lee, Adam
Frattini, Lucia
Rostami, Shahrebano

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