Koloverou, E., Panagiotakos, D.b., Kyrou, I., Stefanadis, C., Chrysohoou, C., Georgousopoulou, E.n., Skoumas, I., Tousoulis, D. and Pitsavos, C. (2019). Visceral adiposity index outperforms common anthropometric indices in predicting 10-year diabetes risk:Results from the ATTICA study. Diabetes/Metabolism Research and Reviews, 35 (6),
Abstract
Background: Visceral adiposity index (VAI) is a novel marker of visceral adipose tissue accumulation and dysfunction. The study aim was to explore the association of VAI with the 10-year type 2 diabetes mellitus (T2DM) incidence in apparently healthy individuals and compare its T2DM predictive ability against common anthropometric indices. Methods: In 2001 to 2002, the ATTICA study (Greece) recruited a random sample of 1514 and 1528 CVD-free men (18-87 years old) and women (18-89 years old), respectively. Sociodemographic, lifestyle, clinical, and biochemical characteristics of participants were measured at baseline, and the 10-year follow-up was performed during 2011 to 2012. After excluding participants with diabetes at baseline and participants without complete follow-up information regarding diabetes status and/or baseline VAI values, the working sample consisted of 1049 participants. In this sample, the predictive value of baseline VAI value was studied in relation to 10-year diabetes incidence. Results: One hundred thirty-three incident cases of diabetes were documented (10-year incidence: 12.7%). In the fully adjusted model, VAI significantly increased diabetes risk by 22% (OR per 1-unit increase =1.22; 95%CI, 1.09-1.37). Markers of oxidative stress and inflammation were found to, at least partly, mediate this relationship. Also, a moderating effect of menstruation status was revealed among women. VAI showed the highest predictive ability and contributed the most, along with waist-to-height ratio, to the correct classification of participants who developed diabetes. Conclusions: The present findings suggest that VAI may be a useful index for predicting long-term diabetes development and may exhibit better predictive ability to commonly used anthropometric indices.
Publication DOI: | https://doi.org/10.1002/dmrr.3161 |
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Divisions: | College of Health & Life Sciences > Aston Medical School |
Additional Information: | This is the peer reviewed version of the following article: Koloverou, E, Panagiotakos, DB, Kyrou, I, et al. Visceral Adiposity Index (VAI) outperforms common anthropometric indices in predicting 10‐year diabetes risk: results from the ATTICA study. Diabetes Metab Res Rev. 2019;e3161, which has been published in final form at https://doi.org/10.1002/dmrr.3161. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving. |
Uncontrolled Keywords: | VAI,anthropometric indices,prognostic markers,type 2 diabetes,visceral adiposity index,Internal Medicine,Endocrinology, Diabetes and Metabolism,Endocrinology |
Publication ISSN: | 1520-7560 |
Last Modified: | 06 Aug 2024 08:21 |
Date Deposited: | 02 Apr 2019 14:06 |
Full Text Link: | |
Related URLs: |
https://onlinel ... .1002/dmrr.3161
(Publisher URL) http://www.scop ... tnerID=8YFLogxK (Scopus URL) |
PURE Output Type: | Article |
Published Date: | 2019-09-01 |
Published Online Date: | 2019-03-25 |
Accepted Date: | 2019-03-21 |
Authors: |
Koloverou, E.
Panagiotakos, D.b. Kyrou, I. ( ![]() Stefanadis, C. Chrysohoou, C. Georgousopoulou, E.n. Skoumas, I. Tousoulis, D. Pitsavos, C. |