Targeting the choroid plexus-CSF-brain nexus using peptides identified by phage display.

Abstract

Drug delivery to the central nervous system requires the use of specific portals to enable drug entry into the brain and, as such, there is a growing need to identify processes that can enable drug transfer across both blood-brain and blood-cerebrospinal fluid barriers. Phage display is a powerful combinatorial technique that identifies specific peptides that can confer new activities to inactive particles. Identification of these peptides is directly dependent on the specific screening strategies used for their selection and retrieval. This chapter describes three selection strategies, which can be used to identify peptides that target the choroid plexus (CP) directly or for drug translocation across the CP and into cerebrospinal fluid.

Publication DOI: https://doi.org/10.1007/978-1-60761-938-3_25
Divisions: Aston Medical School
College of Health & Life Sciences > Aston Medical School
Additional Information: © Springer Science+Business Media, LLC 2011
Uncontrolled Keywords: Molecular Biology,Genetics
Full Text Link:
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
https://link.sp ... -60761-938-3_25 (Publisher URL)
PURE Output Type: Article
Published Date: 2011-01-01
Authors: Baird, Andrew
Eliceiri, Brian P.
Gonzalez, Ana Maria
Johanson, Conrad E.
Leadbeater, Wendy (ORCID Profile 0000-0003-3141-9421)
Stopa, Edward G.

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