Concise Review:Dental Pulp Stem Cells: A Novel Cell Therapy for Retinal and Central Nervous System Repair


Dental pulp stem cells (DPSC) are neural crest-derived ecto-mesenchymal stem cells that can relatively easily and non-invasively be isolated from the dental pulp of extracted postnatal and adult teeth. Accumulating evidence suggests that DPSC have great promise as a cellular therapy for central nervous system (CNS) and retinal injury and disease. The mode of action by which DPSC confer therapeutic benefit may comprise multiple pathways, in particular, paracrine-mediated processes which involve a wide array of secreted trophic factors and is increasingly regarded as the principal predominant mechanism. In this concise review, we present the current evidence for the use of DPSC to repair CNS damage, including recent findings on retinal ganglion cell neuroprotection and regeneration in optic nerve injury and glaucoma. Stem Cells 2017;35:61–67.

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Divisions: College of Health & Life Sciences > Aston Medical School
Funding Information: This work was supported by The Rosetrees Trust and BBSRC (BB/F017553/1).
Additional Information: This is the peer reviewed version of the following article: Mead, B. , Logan, A. , Berry, M. , Leadbeater, W. and Scheven, B. A. (2017), Concise Review: Dental Pulp Stem Cells: A Novel Cell Therapy for Retinal and Central Nervous System Repair. Stem Cells, 35: 61-67, which has been published in final form at  This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
Uncontrolled Keywords: CNS,Dental pulp stem cells,glaucoma,mesenchymal stem cells,nerve repair,neural regeneration,optic nerve,retinal ganglion cells,Molecular Medicine,Developmental Biology,Cell Biology
Publication ISSN: 1066-5099
Last Modified: 15 Apr 2024 07:32
Date Deposited: 19 Mar 2019 11:15
Full Text Link: https://researc ... a4cf29e1e).html
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
https://stemcel ... .1002/stem.2398 (Publisher URL)
PURE Output Type: Review article
Published Date: 2016-12-01
Published Online Date: 2016-06-07
Accepted Date: 2016-04-29
Authors: Mead, Ben
Logan, Ann
Berry, Martin
Leadbeater, Wendy (ORCID Profile 0000-0003-3141-9421)
Scheven, Ben A.



Version: Accepted Version

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