Saffron (Crocus sativus L.) in ocular diseases:a narrative review of the existing evidence from clinical studies

Abstract

Saffron (Crocus sativus L.) and its main constituents, i.e., crocin and crocetin, are natural carotenoid compounds, which have been reported to possess a wide spectrum of properties and induce pleiotropic anti-inflammatory, anti-oxidative, and neuroprotective effects. An increasing number of experimental, animal, and human studies have investigated the effects and mechanistic pathways of these compounds in order to assess their potential therapeutic use in ocular diseases (e.g., in age related macular degeneration, glaucoma, and diabetic maculopathy). This narrative review presents the key findings of published clinical studies that examined the effects of saffron and/or its constituents in the context of ocular disease, as well as an overview of the proposed underlying mechanisms mediating these effects.

Publication DOI: https://doi.org/10.3390/nu11030649
Divisions: College of Health & Life Sciences > School of Optometry > Optometry & Vision Science Research Group (OVSRG)
College of Health & Life Sciences
College of Health & Life Sciences > School of Optometry > Optometry
College of Health & Life Sciences > School of Optometry > Vision, Hearing and Language
College of Health & Life Sciences > School of Biosciences > Cell & Tissue Biomedical Research
College of Health & Life Sciences > School of Biosciences
College of Health & Life Sciences > Chronic and Communicable Conditions
College of Health & Life Sciences > Aston Medical School
Additional Information: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Uncontrolled Keywords: AMD,Anti-inflammatory,Anti-oxidant,Crocetin,Crocin,Crocus Sativus L,Diabetes,Glaucoma,Saffron,Supplements,Food Science,Nutrition and Dietetics
Publication ISSN: 2072-6643
Last Modified: 17 Jun 2024 07:39
Date Deposited: 18 Mar 2019 09:46
Full Text Link:
Related URLs: https://www.mdp ... 43/11/3/649/htm (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Review article
Published Date: 2019-03-18
Accepted Date: 2019-03-13
Authors: Heitmar, Rebekka (ORCID Profile 0000-0002-7657-1788)
Brown, James E (ORCID Profile 0000-0002-3504-7373)
Kyrou, Ioannis (ORCID Profile 0000-0002-6997-3439)

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