Morgan, Nicola, Stanford, Ian and Woodhall, Gavin (2008). Modulation of network oscillatory activity and GABAergic synaptic transmission by CB1 cannabinoid receptors in the rat medial entorhinal cortex. Neural Plasticity, 2008 ,
Abstract
Cannabinoids modulate inhibitory GABAergic neurotransmission in many brain regions. Within the temporal lobe, cannabinoid receptors are highly expressed, and are located presynaptically at inhibitory terminals. Here, we have explored the role of type-1 cannabinoid receptors (CB1Rs) at the level of inhibitory synaptic currents and field-recorded network oscillations. We report that arachidonylcyclopropylamide, an agonist at CB1R, inhibits GABAergic synaptic transmission onto both superficial and deep medial entorhinal (mEC) neurones, but this has little effect on network oscillations in beta/gamma frequency bands. By contrast, the CB1R antagonist/inverse agonist LY320135 (500?nM), increased GABAergic synaptic activity and beta/gamma oscillatory activity in superficial mEC, was suppressed, whilst that in deep mEC was enhanced. These data indicate that cannabinoid-mediated effects on inhibitory synaptic activity may be constitutively active in vitro, and that modulation of CB1R activation using inverse agonists unmasks complex effects of CBR function on network activity.
Publication DOI: | https://doi.org/10.1155/2008/808564 |
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Divisions: | College of Health & Life Sciences > Aston Pharmacy School College of Health & Life Sciences > Clinical and Systems Neuroscience College of Health & Life Sciences > Aston Institute of Health & Neurodevelopment (AIHN) College of Health & Life Sciences |
Additional Information: | Copyright © 2008 Nicola H. Morgan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Uncontrolled Keywords: | entorhinal cortex,cannabinoid,Clinical Neurology,Neurology |
Publication ISSN: | 1687-5443 |
Last Modified: | 05 Aug 2024 10:40 |
Date Deposited: | 11 Mar 2019 18:20 |
Full Text Link: |
http://www.hind ... np/2008/808564/ |
Related URLs: |
http://www.scop ... tnerID=8YFLogxK
(Scopus URL) |
PURE Output Type: | Article |
Published Date: | 2008-06-19 |
Authors: |
Morgan, Nicola
Stanford, Ian ( ![]() Woodhall, Gavin ( ![]() |