Reproducibility and repeatability of the OcuSense TearLab™ osmometer


BACKGROUND: Some studies report that increased tear osmolarity is a reliable indicator of dry eye syndrome (DES). The OcuSense TearLab™ osmometer requires less than a 100-nl sample of tears and provides an instant quantitative result. Our aim was to clinically evaluate this instrument in terms of its reproducibility and repeatability. METHODS: Twenty-nine participants who ranged in age from 19 to 49 years (mean?±?SD: 23.3?±?5.5 years) were recruited. Osmolarity readings were collected by two operators, in two sessions separated by 1 or 2 weeks in order to assess test reproducibility and repeatability. RESULTS: The coefficient of reproducibility was 39 mOsms/l; the coefficient of repeatability was 33 mOsms/l. CONCLUSIONS: Our mean coefficient of variation over four readings for 29 subjects is 2.9%, which compares well with that reported by the manufacturer. Our results inform practitioners about the level of change over time that can be considered clinically relevant for healthy subjects. This value is 33mOsms/l; any change smaller than this could be attributed to measurement noise.

Publication DOI:
Divisions: College of Health & Life Sciences > School of Optometry > Optometry
College of Health & Life Sciences > School of Optometry > Optometry & Vision Science Research Group (OVSRG)
College of Health & Life Sciences
College of Health & Life Sciences > School of Optometry > Vision, Hearing and Language
Additional Information: The original publication is available at
Uncontrolled Keywords: dry eye,osmolarity,osmometer,TearLab,tears,Ophthalmology,Sensory Systems,Cellular and Molecular Neuroscience
Publication ISSN: 1435-702X
Last Modified: 17 May 2024 07:08
Date Deposited: 11 Mar 2019 18:08
Full Text Link: http://www.spri ... 544546u5542835/
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2012-08
Published Online Date: 2012-02-21
Authors: Eperjesi, Frank (ORCID Profile 0000-0003-4358-0095)
Aujla, Maana
Bartlett Eperjesi, Hannah (ORCID Profile 0000-0002-7531-6902)

Export / Share Citation


Additional statistics for this record