The effect of voluntary fasting and dehydration on flicker-induced retinal vascular dilation in a healthy individual: a case report


INTRODUCTION: Dynamic retinal vessel analysis represents a well-established method for the assessment of vascular reactivity during both normal conditions and after various provocations. We present a case where the subject showed abnormal retinal vessel reactivity after fasting voluntarily for 20 hours. CASE PRESENTATION: A healthy, 21-year-old man who fasted voluntarily for 20 hours exhibited abnormal retinal vascular reactivity (dilation and constriction) after flicker provocation as measured using the Dynamic Retinal Vessel Analyser (Imedos, Jena, Germany). CONCLUSION: The abnormal vascular reactivity induced by fasting was significant; abnormal levels of important nutrients due to fasting and dehydration could play a role through altering the concentration of vasoactive substances such as nitric oxide. This hypothesis needs further investigation.

Publication DOI:
Divisions: College of Health & Life Sciences > School of Optometry > Optometry
College of Health & Life Sciences > School of Optometry > Optometry & Vision Science Research Group (OVSRG)
College of Health & Life Sciences
College of Health & Life Sciences > School of Optometry > Vision, Hearing and Language
College of Health & Life Sciences > Clinical and Systems Neuroscience
Additional Information: © 2008 Heitmar et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Uncontrolled Keywords: dynamic retinal vessel analysis,assessment,vascular reactivity,abnormal retinal vessel reactivity,fasting,Medicine(all)
Publication ISSN: 1752-1947
Last Modified: 02 Jan 2024 08:13
Date Deposited: 11 Mar 2019 17:48
Full Text Link:
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
http://www.jmed ... content/2/1/153 (Publisher URL)
PURE Output Type: Article
Published Date: 2008-05-13
Authors: Heitmar, Rebekka (ORCID Profile 0000-0002-7657-1788)
Gherghel, Doina (ORCID Profile 0000-0001-9439-5573)
Armstrong, Richard A. (ORCID Profile 0000-0002-5046-3199)
Cubbidge, Robert P (ORCID Profile 0000-0002-7851-1375)
Hosking, Sarah



Version: Published Version

License: Creative Commons Attribution

| Preview

Export / Share Citation


Additional statistics for this record