Thiosemicarbazones active against Clostridium difficile


A set of closely related furylidene thiosemicarbazones was prepared and screened against various clinically important Gram-positive bacteria. One compound containing an ethylene spacer and a 5-nitrofuryl group was found to have promising activity against Clostridium difficile.

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Divisions: College of Health & Life Sciences
College of Health & Life Sciences > Chronic and Communicable Conditions
College of Health & Life Sciences > School of Biosciences
College of Health & Life Sciences > Aston Pharmacy School
College of Health & Life Sciences > School of Biosciences > Cellular and Molecular Biomedicine
Additional Information: NOTICE: this is the author’s version of a work that was accepted for publication in Bioorganic and Medicinal Chemistry Letters. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Costello, Cait; Karpanen, Tarja; Lambert, Peter A.; Mistry, Preena; Parker, Katy J.; Rathbone, Daniel L.; Ren, Jiangmeng; Wheeldon, Laura and Worthington, Tony (2008). Thiosemicarbazones active against Clostridium difficile. Bioorganic and Medicinal Chemistry Letters, 18 (5), pp. 1708-1711. DOI 10.1016/j.bmcl.2008.01.041
Uncontrolled Keywords: thiosemicarbazone,Clostridium difficile,antimicrobial,nitrofuran,Biochemistry,Molecular Biology,Organic Chemistry,Drug Discovery,Pharmaceutical Science
Publication ISSN: 1464-3405
Last Modified: 29 May 2024 07:08
Date Deposited: 11 Mar 2019 17:47
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2008-03-01
Authors: Costello, Cait
Karpanen, Tarja
Lambert, Peter A. (ORCID Profile 0000-0002-8243-2741)
Mistry, Preena
Parker, Katy J.
Rathbone, Daniel L. (ORCID Profile 0000-0003-4732-4662)
Ren, Jiangmeng
Wheeldon, Laura
Worthington, Tony (ORCID Profile 0000-0002-1906-3357)

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