Costello, Cait, Karpanen, Tarja, Lambert, Peter A., Mistry, Preena, Parker, Katy J., Rathbone, Daniel L., Ren, Jiangmeng, Wheeldon, Laura and Worthington, Tony (2008). Thiosemicarbazones active against Clostridium difficile. Bioorganic and Medicinal Chemistry Letters, 18 (5), pp. 1708-1711.
Abstract
A set of closely related furylidene thiosemicarbazones was prepared and screened against various clinically important Gram-positive bacteria. One compound containing an ethylene spacer and a 5-nitrofuryl group was found to have promising activity against Clostridium difficile.
| Publication DOI: | https://doi.org/10.1016/j.bmcl.2008.01.041 |
|---|---|
| Divisions: | College of Health & Life Sciences College of Health & Life Sciences > Chronic and Communicable Conditions College of Health & Life Sciences > School of Biosciences College of Health & Life Sciences > Aston Pharmacy School College of Health & Life Sciences > School of Biosciences > Cellular and Molecular Biomedicine Aston University (General) |
| Additional Information: | NOTICE: this is the author’s version of a work that was accepted for publication in Bioorganic and Medicinal Chemistry Letters. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Costello, Cait; Karpanen, Tarja; Lambert, Peter A.; Mistry, Preena; Parker, Katy J.; Rathbone, Daniel L.; Ren, Jiangmeng; Wheeldon, Laura and Worthington, Tony (2008). Thiosemicarbazones active against Clostridium difficile. Bioorganic and Medicinal Chemistry Letters, 18 (5), pp. 1708-1711. DOI 10.1016/j.bmcl.2008.01.041 |
| Uncontrolled Keywords: | thiosemicarbazone,Clostridium difficile,antimicrobial,nitrofuran,Biochemistry,Molecular Biology,Organic Chemistry,Drug Discovery,Pharmaceutical Science |
| Publication ISSN: | 1464-3405 |
| Last Modified: | 04 Nov 2024 08:10 |
| Date Deposited: | 11 Mar 2019 17:47 |
| Full Text Link: | |
| Related URLs: |
http://www.scop ... tnerID=8YFLogxK
(Scopus URL) |
PURE Output Type: | Article |
| Published Date: | 2008-03-01 |
| Authors: |
Costello, Cait
Karpanen, Tarja Lambert, Peter A. ( 
0000-0002-8243-2741)
Mistry, Preena Parker, Katy J. Rathbone, Daniel L. (
0000-0003-4732-4662)
Ren, Jiangmeng Wheeldon, Laura Worthington, Tony (
0000-0002-1906-3357)
|
CORE (COnnecting REpositories)
CORE (COnnecting REpositories)