Limitations of the isolated GP-STN network


An in vitro mouse slice preparation from control and MPTP-treated mice in which functional reciprocal GP-STN connectivity is maintained, does not produce oscillatory bursting or synchronous activity neuronal activity. Pharmacological interventions that produce bursting activity do so without concomitant neuronal synchrony, or a requirement for glutamate or GABA transmission. Pre-treatment with MPTP did not alter this behaviour. Thus, we have no evidence that the functionally connected, but isolated, GP — STN network can act as a pacemaker for synchronous correlated activity in the basal ganglia and must conclude that other inputs such as those from cortex and/or striatum are required.

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Divisions: College of Health & Life Sciences > Aston Pharmacy School
College of Health & Life Sciences > Clinical and Systems Neuroscience
College of Health & Life Sciences > Aston Institute of Health & Neurodevelopment (AIHN)
College of Health & Life Sciences
Additional Information: 8th Triennial Meeting of the International-Basal-Ganglia-Society, Crieff, Scotland, 5-9 September 2004
Event Title: Basal Ganglia VIII
Event Type: Other
Event Dates: 2005-12-25 - 2005-12-25
ISBN: 9780387280653
Last Modified: 11 Mar 2024 08:06
Date Deposited: 11 Mar 2019 16:37
Full Text Link:
Related URLs: http://www.spri ... cead144484&pi=5 (Publisher URL)
PURE Output Type: Chapter
Published Date: 2005-12-25
Authors: Stanford, Ian M. (ORCID Profile 0000-0002-5677-8538)
Loucif, K.C.
Wilson, Clare L.
Cash, D.
Lacey, M.G.



Version: Accepted Version

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