IMI - Clinical Myopia Control Trials and Instrumentation Report


The evidence-basis based on existing myopia control trials along with the supporting academic literature were reviewed; this informed recommendations on the outcomes suggested from clinical trials aimed at slowing myopia progression to show the effectiveness of treatments and the impact on patients. These outcomes were classified as primary (refractive error and/or axial length), secondary (patient reported outcomes and treatment compliance), and exploratory (peripheral refraction, accommodative changes, ocular alignment, pupil size, outdoor activity/lighting levels, anterior and posterior segment imaging, and tissue biomechanics). The currently available instrumentation, which the literature has shown to best achieve the primary and secondary outcomes, was reviewed and critiqued. Issues relating to study design and patient selection were also identified. These findings and consensus from the International Myopia Institute members led to final recommendations to inform future instrumentation development and to guide clinical trial protocols.

Publication DOI:
Divisions: College of Health & Life Sciences > School of Optometry > Optometry & Vision Science Research Group (OVSRG)
College of Health & Life Sciences
College of Health & Life Sciences > School of Optometry > Vision, Hearing and Language
College of Health & Life Sciences > School of Optometry > Optometry
Additional Information: Copyright 2019 The Authors. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
Uncontrolled Keywords: Clinical trial guidelines,Instrumentation,Myopia control,Myopia progression,Recommendations,Internationality,Humans,Randomized Controlled Trials as Topic/standards,Evidence-Based Medicine,Myopia/diagnosis,Disease Progression,Ophthalmology,Sensory Systems,Cellular and Molecular Neuroscience
Publication ISSN: 1552-5783
Last Modified: 10 Jun 2024 07:31
Date Deposited: 07 Mar 2019 12:45
Full Text Link:
Related URLs: ... ticleid=2727316 (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Review article
Published Date: 2019-02-28
Accepted Date: 2018-10-20
Authors: Wolffsohn, James S (ORCID Profile 0000-0003-4673-8927)
Kollbaum, Pete S
Berntsen, David A
Atchison, David A
Benavente, Alexandra
Bradley, Arthur
Buckhurst, Hetal
Collins, Michael
Fujikado, Takashi
Hiraoka, Takahiro
Hirota, Masakazu
Jones, Debbie
Logan, Nicola S (ORCID Profile 0000-0002-0538-9516)
Lundström, Linda
Torii, Hidemasa
Read, Scott A
Naidoo, Kovin

Export / Share Citation


Additional statistics for this record