Allsop, Thomas D.P., Neal, Ronald, Wang, Changle, Nagel, David A, Hine, Anna V., Culverhouse, Philip F., Ania-Castañón, Juan Diego, Webb, David J, Scarano, Simona and Minunni, Maria (2019). An ultra-sensitive aptasensor on optical fibre for the direct detection of Bisphenol A. Biosensors and Bioelectronics, 135 , pp. 102-110.
Abstract
We present a plasmonic biosensor capable of detecting the presence of bisphenol A in ultralow concentrations, yielding a wavelength shift of 0.15±0.01 nm in response to a solution of 1 fM concentration with limit of detection of 330±70 aM. The biosensing device consists of an array of gold nano-antennae with a total length of 2.3cm that generate coupled localised surface plasmons (cLSPs) and is covalently modified with an aptamer specific for bisphenol A recognition. The array of nanoantennae is fabricated on a lapped section of standard telecommunication optical fibre, allowing for potential multiplexing and its use in remote sensing applications. These results have been achieved without the use of enhancement techniques and therefore the approach allows the direct detection of bisphenol A, a low molecular weight (228 Da) target usually detectable only by indirect detection strategies. Its detection at such levels is a significant step forward in measuring small molecules at ultralow concentrations. Furthermore, this new sensing platform paves the way for the development of portable systems for in-situ agricultural measurements capable of retrieving data on a substance of very high concern at ultra-low concentrations.
Publication DOI: | https://doi.org/10.1016/j.bios.2019.02.043 |
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Divisions: | College of Health & Life Sciences > School of Biosciences College of Health & Life Sciences College of Engineering & Physical Sciences > Aston Institute of Photonics Technology (AIPT) |
Additional Information: | © 2019, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ Funding: EPSRC EP/J010413 and EP/J01039; MIUR scientific program SIR2014 Scientific Independence of young Researchers (RBSI1455LK). |
Uncontrolled Keywords: | Aptamers,Biosensors,Bisphenol A,Fibre optics,Nanostructures,Plasmonics,Biotechnology,Biophysics,Biomedical Engineering,Electrochemistry |
Publication ISSN: | 1873-4235 |
Last Modified: | 21 Nov 2024 08:10 |
Date Deposited: | 06 Mar 2019 09:51 |
Full Text Link: | |
Related URLs: |
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(Publisher URL) http://www.scop ... tnerID=8YFLogxK (Scopus URL) |
PURE Output Type: | Article |
Published Date: | 2019-06-15 |
Published Online Date: | 2019-02-22 |
Accepted Date: | 2019-02-15 |
Authors: |
Allsop, Thomas D.P.
Neal, Ronald Wang, Changle Nagel, David A ( 0000-0002-9055-1775) Hine, Anna V. ( 0000-0003-4065-831X) Culverhouse, Philip F. Ania-Castañón, Juan Diego Webb, David J ( 0000-0002-5495-1296) Scarano, Simona Minunni, Maria |
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