An ultra-sensitive aptasensor on optical fibre for the direct detection of Bisphenol A


We present a plasmonic biosensor capable of detecting the presence of bisphenol A in ultralow concentrations, yielding a wavelength shift of 0.15±0.01 nm in response to a solution of 1 fM concentration with limit of detection of 330±70 aM. The biosensing device consists of an array of gold nano-antennae with a total length of 2.3cm that generate coupled localised surface plasmons (cLSPs) and is covalently modified with an aptamer specific for bisphenol A recognition. The array of nanoantennae is fabricated on a lapped section of standard telecommunication optical fibre, allowing for potential multiplexing and its use in remote sensing applications. These results have been achieved without the use of enhancement techniques and therefore the approach allows the direct detection of bisphenol A, a low molecular weight (228 Da) target usually detectable only by indirect detection strategies. Its detection at such levels is a significant step forward in measuring small molecules at ultralow concentrations. Furthermore, this new sensing platform paves the way for the development of portable systems for in-situ agricultural measurements capable of retrieving data on a substance of very high concern at ultra-low concentrations.

Publication DOI:
Divisions: College of Health & Life Sciences > School of Biosciences
College of Health & Life Sciences
College of Engineering & Physical Sciences > Aston Institute of Photonics Technology (AIPT)
Additional Information: © 2019, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Funding: EPSRC EP/J010413 and EP/J01039; MIUR scientific program SIR2014 Scientific Independence of young Researchers (RBSI1455LK).
Uncontrolled Keywords: Aptamers,Biosensors,Bisphenol A,Fibre optics,Nanostructures,Plasmonics,Biotechnology,Biophysics,Biomedical Engineering,Electrochemistry
Publication ISSN: 1873-4235
Last Modified: 14 Jun 2024 07:17
Date Deposited: 06 Mar 2019 09:51
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Related URLs: https://www.sci ... sd_search_email (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2019-06-15
Published Online Date: 2019-02-22
Accepted Date: 2019-02-15
Authors: Allsop, Thomas D.P.
Neal, Ronald
Wang, Changle
Nagel, David A (ORCID Profile 0000-0002-9055-1775)
Hine, Anna V. (ORCID Profile 0000-0003-4065-831X)
Culverhouse, Philip F.
Ania-Castañón, Juan Diego
Webb, David J (ORCID Profile 0000-0002-5495-1296)
Scarano, Simona
Minunni, Maria

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