Endothelial dysfunction and preeclampsia: role of oxidative stress


Preeclampsia (PE) is an often fatal pathology characterized by hypertension and proteinuria at the 20th week of gestation that affects 5–10% of the pregnancies. The problem is particularly important in developing countries in where the incidence of hypertensive disorders of pregnancy is higher and maternal mortality rates are 20 times higher than those reported in developed countries. Risk factors for the development of PE include obesity, insulin resistance and hyperlipidemia that stimulate inflammatory cytokine release and oxidative stress leading to endothelial dysfunction (ED). However, how all these clinical manifestations concur to develop PE is still not very well understood. The related poor trophoblast invasion and uteroplacental artery remodeling described in PE, increases reactive oxygen species (ROS), hypoxia and ED. Here we aim to review current literature from research showing the interplay between oxidative stress, ED and PE to the outcomes of current clinical trials aiming to prevent PE with antioxidant supplementation.

Publication DOI: https://doi.org/10.3389/fphys.2014.00372
Divisions: College of Health & Life Sciences > Aston Medical School
Additional Information: © 2014 Sánchez-Aranguren, Prada, Riaño-Medina and Lopez. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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Related URLs: https://www.fro ... 2014.00372/full (Publisher URL)
PURE Output Type: Review article
Published Date: 2014-10-10
Authors: Sanchez Aranguren, Lissette (ORCID Profile 0000-0002-4663-5752)
Prada, Carlos E.
Riaño-Medina, Carlos E.
López, Marcos



Version: Published Version

License: Creative Commons Attribution

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