Investigating Voice as a Biomarker for Leucine-Rich Repeat Kinase 2-Associated Parkinson's Disease


We investigate the potential association between leucine-rich repeat kinase 2 (LRRK2) mutations and voice. Sustained phonations ('aaah' sounds) were recorded from 7 individuals with LRRK2-associated Parkinson's disease (PD), 17 participants with idiopathic PD (iPD), 20 non-manifesting LRRK2-mutation carriers, 25 related non-carriers, and 26 controls. In distinguishing LRRK2-associated PD and iPD, the mean sensitivity was 95.4% (SD 17.8%) and mean specificity was 89.6% (SD 26.5%). Voice features for non-manifesting carriers, related non-carriers, and controls were much less discriminatory. Vocal deficits in LRRK2-associated PD may be different than those in iPD. These preliminary results warrant longitudinal analyses and replication in larger cohorts.

Publication DOI:
Divisions: College of Engineering & Physical Sciences > Systems analytics research institute (SARI)
Additional Information: ©2018 IOS Press.
Uncontrolled Keywords: biomarker,LRRK2 mutation,Parkinson’s disease,voice,Clinical Neurology,Cellular and Molecular Neuroscience
Publication ISSN: 1877-718X
Last Modified: 01 Apr 2024 07:28
Date Deposited: 05 Nov 2018 10:47
Full Text Link:
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
https://content ... sease/jpd181389 (Publisher URL)
PURE Output Type: Article
Published Date: 2018-10-17
Accepted Date: 2018-08-13
Authors: Arora, Siddharth
Visanji, Naomi P.
Mestre, Tiago A.
Tsanas, Athanasios
AlDakheel, Amaal
Connolly, Barbara S.
Gasca-Salas, Carmen
Kern, Drew S.
Jain, Jennifer
Slow, Elizabeth J.
Faust-Socher, Achinoam
Lang, Anthony E.
Little, Max A. (ORCID Profile 0000-0002-1507-3822)
Marras, Connie



Version: Accepted Version

| Preview

Export / Share Citation


Additional statistics for this record