Aquaporins and Their Regulation after Spinal Cord Injury

Abstract

After injury to the spinal cord, edema contributes to the underlying detrimental pathophysiological outcomes that lead to worsening of function. Several related membrane proteins called aquaporins (AQPs) regulate water movement in fluid transporting tissues including the spinal cord. Within the cord, AQP1, 4 and 9 contribute to spinal cord injury (SCI)-induced edema. AQP1, 4 and 9 are expressed in a variety of cells including astrocytes, neurons, ependymal cells, and endothelial cells. This review discusses some of the recent findings of the involvement of AQP in SCI and highlights the need for further study of these proteins to develop effective therapies to counteract the negative effects of SCI-induced edema.

Publication DOI: https://doi.org/10.3390/cells7100174
Divisions: College of Health & Life Sciences > School of Biosciences
College of Health & Life Sciences
College of Health & Life Sciences > School of Biosciences > Cellular and Molecular Biomedicine
Additional Information: © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Full Text Link:
Related URLs: http://www.mdpi ... 3-4409/7/10/174 (Publisher URL)
PURE Output Type: Review article
Published Date: 2018-10-18
Accepted Date: 2018-10-13
Authors: Halsey, Andrea M
Conner, Alex C
Bill, Roslyn M (ORCID Profile 0000-0003-1331-0852)
Logan, Ann
Ahmed, Zubair

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