Lipid accumulation product in relation to 10-year cardiovascular disease incidence in Caucasian adults: The ATTICA study


Background and aims The lipid accumulation product (LAP) is an index describing lipid over-accumulation based on waist circumference (WC) and fasting triglycerides, and can outperform the body mass index (BMI) in recognizing cardiovascular disease (CVD) risk. We aimed to explore the association of LAP with long-term CVD risk and compare its CVD-predictive value against common anthropometric indices/ratios of obesity. Methods ATTICA is a prospective, population-based cohort that recruited 3042 adults without pre-existing CVD from the Greek general population (age 18–89 years; 1514 men). The 10-year study follow-up (2011–2012) captured the fatal/non-fatal CVD incidence in 2020 participants (50% men). Baseline LAP (cm⋅mmol/L) was calculated and analyzed in relation to the 10-year CVD incidence. Results In total, 317 CVD cases (15.7%) were documented during the follow-up. Baseline LAP showed a significant positive association with the 10-year CVD incidence, even after adjusting for hypertension, diabetes, hypercholesterolemia, smoking, physical activity, Mediterranean diet adherence, and key pro-inflammatory biomarkers (Hazard Ratios per 10 cm mmol/L of LAP ranging from 1.1 to 1.21, p = 0.04). Moreover, LAP predicted the 10-year CVD study incidence better than common obesity indices (BMI, WC, waist-to-hip, waist-to-height ratio). Conclusions These findings support and independent positive association between LAP and long-term CVD incidence in CVD-free Caucasian adults from the general population.

Publication DOI:
Divisions: College of Health & Life Sciences > Aston Medical School
Additional Information: © 2018, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Publication ISSN: 1879-1484
Last Modified: 20 May 2024 07:25
Date Deposited: 22 Oct 2018 09:24
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Related URLs: https://linking ... 021915018314345 (Publisher URL)
PURE Output Type: Article
Published Date: 2018-12-01
Published Online Date: 2018-10-17
Accepted Date: 2018-10-16
Authors: Kyrou, Ioannis (ORCID Profile 0000-0002-6997-3439)
Panagiotakos, Demosthenes B.
Kouli, Georgia-maria
Georgousopoulou, Ekavi
Chrysohoou, Christina
Tsigos, Constantine
Tousoulis, Dimitrios
Pitsavos, Christos

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