Noninvasive control of rhodamine-loaded capsules distribution in vivo


Using fluorescence spectroscopy system with fibre-optical probe, we investigated the dynamics of propagation and circulation in the microcirculatory system of experimental nanocapsules fluorescent-labelled (rhodamine TRITC) nanocapsules. The studies were carried out in clinically healthy Wistar rats. The model animals were divided into control group and group received injections of the nanocapsules. The fluorescent measurements conducted transcutaneously on the thigh surface. The administration of the preparation with the rhodamine concentration of 5 mg/kg of animal weight resulted in twofold increase of fluorescence intensity by reference to the baseline level. As a result of the study, it was concluded that fluorescence spectroscopy can be used for transdermal measurements of the rhodamine-loaded capsules in vivo.

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Divisions: College of Engineering & Physical Sciences
College of Engineering & Physical Sciences > Aston Institute of Photonics Technology (AIPT)
Additional Information: Copyright 2018 SPIE. One print or electronic copy may be made for personal use only. Systematic reproduction, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.
Event Title: Fall Meeting 2017: Optical Technologies in Biophysics and Medicine XIX
Event Type: Other
Event Dates: 2017-09-26 - 2017-09-30
Last Modified: 26 Feb 2024 08:09
Date Deposited: 26 Jul 2018 13:46
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Related URLs: https://www.spi ... 5773.full?SSO=1 (Publisher URL)
PURE Output Type: Conference contribution
Published Date: 2018-04-26
Accepted Date: 2017-09-30
Authors: Stelmashchuk, Olga
Tarakanchikova, Y
Seryogina, E
Piavchenko, G
Zherebtsov, Evgeny (ORCID Profile 0000-0002-3635-1430)
Dunaev, Andrey V.
Popov, A
Meglinski, Igor



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