Anti-RSV Peptide-Loaded Liposomes for the Inhibition of Respiratory Syncytial Virus


Although respiratory syncytial virus (RSV) is one of the leading causes of acute respiratory tract infection in infants and adults, effective treatment options remain limited. To circumvent this issue, there is a novel approach, namely, the development of multifunctional liposomes for the delivery of anti RSV-peptides. While most of the peptides that are used for loading with the particulate delivery systems are the penetrating peptides, an alternative approach is the development of liposome-peptide systems, which are loaded with an RSV fusion peptide (RF-482), which has been designed to inhibit the RSV fusion and block infection. The results of this work have revealed that the liposomes themselves can serve as potential RSV inhibitors, whilst the anti-RSV-peptide with liposomes can significantly increase the RSV inhibition when compared with the anti-RSV peptide alone.

Divisions: College of Health & Life Sciences > Aston Pharmacy School
College of Health & Life Sciences > School of Biosciences
College of Health & Life Sciences
College of Health & Life Sciences > Chronic and Communicable Conditions
Additional Information: © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
Publication ISSN: 2306-5354
Last Modified: 29 Nov 2023 11:57
Date Deposited: 03 Jul 2018 15:25
Full Text Link: 10.3390/bioengineering5020037
Related URLs: http://www.mdpi ... 306-5354/5/2/37 (Publisher URL)
PURE Output Type: Article
Published Date: 2018-05-09
Accepted Date: 2018-05-07
Authors: Joshi, Sameer
Chaudhari, Atul A
Dennis, Vida
Kirby, Daniel J
Perrie, Yvonne
Singh, Shree Ram



Version: Published Version

License: Creative Commons Attribution

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