Response of the Aging Eye to First Day of Modern Material Contact Lens Wear

Abstract

Objectives:To investigate the ocular surface of an aged population wearing a daily disposable contact lens (CL) over their 1st day of wear.Methods:Forty eyes from 40 presbyopic subjects were fitted a daily CL (Delefilcon A). Tear osmolarity, tear meniscus area (TMA), and ocular surface aberrations (total higher-order root mean square [RMS]) were assessed at baseline (t 0 ), at 20 min (t 1 ) and after 8 hr (t 2 ) of wear. Fluorescein corneal and conjunctival staining and tear breakup time (TBUT) were performed at t 0 and t 2 .Results:No statistically significant changes were found between t 0 , t 1 , and t 2 for TMA and between t 0 and t 2 for fluorescein corneal and conjunctival staining. Tear breakup time worsened by the end of the day from 10.4±0.4 sec t 0 to 9.0±0.3 sec t 2 (P<0.05). Osmolarity showed significant changes between t 0 306.9±2.3 mOsm/L and t 1 312.4±2.4 mOsmol/L (P=0.02) but returned to baseline values at 8 hr (310.40±2.26 mOsm/L; P=0.09). Total higher-order RMS showed significant changes between t 0 0.38±0.02 m and t 1 0.61±0.04 m (P≤0.001) and between t 0 and t 2 0.64±0.41 m (P≤0.001).Conclusions:Delefilcon A may induce measures changes (osmolarity and TBUT values) in a presbyopic population; however, TMA and vital staining were maintained at the baseline level over the day.