Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017


This report summarises the presentations and activities of the ISEV Workshop on extracellular vesicle biomarkers held in Birmingham, UK during December 2017. Among the key messages was broad agreement about the importance of biospecimen science. Much greater attention needs to be paid towards the provenance of collected samples. The workshop also highlighted clear gaps in our knowledge about pre-analytical factors that alter extracellular vesicles (EVs). The future utility of certified standards for credentialing of instruments and software, to analyse EV and for tracking the influence of isolation steps on the structure and content of EVs were also discussed. Several example studies were presented, demonstrating the potential utility for EVs in disease diagnosis, prognosis, longitudinal serial testing and stratification of patients. The conclusion of the workshop was that more effort focused on pre-analytical issues and benchmarking of isolation methods is needed to strengthen collaborations and advance more effective biomarkers.

Publication DOI:
Divisions: College of Health & Life Sciences > School of Biosciences
College of Health & Life Sciences > School of Biosciences > Cell & Tissue Biomedical Research
College of Health & Life Sciences
College of Health & Life Sciences > Chronic and Communicable Conditions
College of Health & Life Sciences > School of Biosciences > Cellular and Molecular Biomedicine
Additional Information: © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of The International Society for Extracellular Vesicles. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Uncontrolled Keywords: Biomarkers,extracellular vesicles,exomes,cancer,serum,plasma,urine
Publication ISSN: 2001-3078
Full Text Link:
Related URLs: https://www.tan ... 78.2018.1473707 (Publisher URL)
PURE Output Type: Article
Published Date: 2018-05-17
Accepted Date: 2018-04-28
Authors: Clayton, Aled
Buschmann, Dominik
Byrd, J. Brian
Carter, David R. F.
Cheng, Lesley
Compton, Carolyn
Daaboul, George
Devitt, Andrew (ORCID Profile 0000-0002-4651-6761)
Falcon-Perez, Juan Manuel
Gardiner, Chris
Gustafson, Dakota
Harrison, Paul
Helmbrecht, Clemens
Hendrix, An
Hill, Andrew
Hoffman, Andrew
Jones, Jennifer C.
Kalluri, Raghu
Kang, Ji Yoon
Kirchner, Benedikt
Lässer, Cecilia
Lawson, Charlotte
Lenassi, Metka
Levin, Carina
Llorente, Alicia
Martens-Uzunova, Elena S.
Möller, Andreas
Musante, Luca
Ochiya, Takahiro
Pink, Ryan C.
Tahara, Hidetoshi
Wauben, Marca H. M.
Webber, Jason P.
Welsh, Joshua A.
Witwer, Kenneth W.
Yin, Hang
Nieuwland, Rienk



Version: Published Version

License: Creative Commons Attribution

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