Long-term clinical outcomes of cardiac resynchronization therapy with or without defibrillation:impact of the aetiology of cardiomyopathy


Background: There is a continuing debate as to whether cardiac resynchronization therapy-defibrillation (CRT-D) is superior to CRT-pacing (CRT-P), particularly in patients with non-ischemic cardiomyopathy (NICM). Objective: We sought to quantify clinical outcomes after primary prevention CRT-D and CRT-P and whether clinical outcomes differ according to the etiology of cardiomyopathy. Methods: Clinical events were quantified in patients undergoing CRT-D (n = 551) or CRT-P (n = 999). Analyses were undertaken in the total study population and in propensity-matched samples. Device choice was governed by clinical guidelines in the United Kingdom. Results: In univariable analyses of the total study population, (maximum follow-up: 16 years; median of 4.7 years (interquartile range [IQR]: 2.4-7.1), CRT-D was associated with a lower total mortality (HR:0.71) and the composite endpoints of total mortality or HF hospitalization (HR:0.72) and total mortality or hospitalization for major adverse cardiac events (MACE; HR:0.71) (all p < 0.001). After propensity-matching (n = 796), CRT-D was associated with a lower total mortality (HR:0.72) and the composite endpoints (all p < 0.01). When further stratified according to etiology, CRT-D was associated with a lower total mortality (HR:0.62), total mortality or HF hospitalization (HR: 0.63) and total mortality or hospitalization for MACE (HR:0.59) (all p < 0.001) in patients with ischaemic cardiomyopathy (ICM). No difference in outcomes between CRT-D and CRT-P emerged in patients with NICM. Conclusions: In this study of real-world clinical practice, CRT-D was superior to CRT-P with respect to total mortality and composite endpoints, independent of known confounders. The benefit of CRT-D was evident in ICM, but not in NICM.

Publication DOI: https://doi.org/10.1093/europace/eux283
Divisions: College of Business and Social Sciences > Aston Business School > Work & Organisational Psychology
College of Health & Life Sciences > Aston Medical School
Additional Information: © The Author 2018. Published on behalf of the European Society of Cardiology. Funding: Boston Scientific.
Event Title: Heart Rhythm Congress 2017
Event Type: Other
Event Dates: 2017-10-01 - 2017-10-04
Uncontrolled Keywords: electric countershock cardiomyopathy treatment outcome cardiac resynchronization therapy causality
Last Modified: 08 Dec 2023 13:03
Date Deposited: 29 Mar 2018 10:15
Full Text Link:
Related URLs: https://academi ... l_1/i20/4348631 (Publisher URL)
PURE Output Type: Poster
Published Date: 2017-10-05
Published Online Date: 2017-10-05
Accepted Date: 2017-09-30
Authors: Zegard, A.
Umar, F.
Taylor, R.j.
Acquaye, E.
Gubran, C.
Chalil, S.
Patel, K.
Panting, J.
Marshall, H.
Leyva-Leon, Francisco



Access Restriction: Restricted to Repository staff only until 1 January 2050.

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