Meta-Analysis and Systematic Review of Neural Stem Cells therapy for experimental ischemia stroke in preclinical studies


To evaluate the preclinical studies using NSCs transplantation therapy for experimental ischemic stroke, and determine the effect size of NSCs therapy and the correlations between different clinical measures. We firstly searched literatures to identify studies of NSCs therapy in animal cerebral ischemia models, and then calculated the quality score of studies, assessed the effect size of NSCs therapy relative to behavioral and histologic endpoints by meta-analysis. A total of 37 studies and 54 independent treated interventions were used for systematic review and meta-analysis. The median quality score was 5 of 10. 36 studies (53 intervention arms) reported functional outcome, 22 studies (34 intervention arms) reported structural outcome. After adjusted by subgroup and sensitivity analysis, the mean effect sizes were improved by 1.35 for mNSS, 1.84 for rotarod test, 0.61 for cylinder test, and 0.84 for infarct volume. Furthermore, effect size had a certain interaction with clinical variables, for example early NSCs therapy etc. In this preclinical studies, we demonstrated that transplanted NSCs significantly improved outcomes (both functional and structural outcome) in ischemic stroke. It is suggested that future preclinical animal model studies of stroke should improve study quality validity and reduce potentially confounded publication bias.

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Divisions: College of Health & Life Sciences > Aston Medical School
Additional Information: © The Author(s) 2016. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit Funding: National Natural Science Foundation of China (No. 81471780).
Uncontrolled Keywords: Preclinical research, Stem-cell research
Publication ISSN: 2045-2322
Last Modified: 29 Apr 2024 07:23
Date Deposited: 12 Mar 2018 13:25
Full Text Link: http://www.natu ... icles/srep32291
Related URLs: http://www.natu ... icles/srep32291 (Publisher URL)
PURE Output Type: Article
Published Date: 2016-08-24
Published Online Date: 2016-08-24
Accepted Date: 2016-08-05
Authors: Chen, Lukui
Zhang, Guilong
Gu, Yuchun (ORCID Profile 0000-0002-7558-0447)
Guo, Xiaoyuan



Version: Published Version

License: Creative Commons Attribution

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