Clinical Efficacy and Meta-Analysis of Stem Cell Therapies for Patients with Brain Ischemia


Objective. Systematic review and meta-analysis to observe the efficacy and safety of stem cell transplantation therapy in patients with brain ischemia. Methods. We searched Cochrane Library, PubMed, Ovid, CBM, CNKI, WanFang, and VIP Data from its inception to December 2015, to collect randomized controlled trials (RCT) of stem cell transplantation for the ischemic stroke. Two authors independently screened the literature according to the inclusion and exclusion criteria, extracted data, and assessed the risk of bias. Thereafter, meta-analysis was performed. Results. Sixteen studies and eighteen independent treatments were included in the current meta-analysis. The results based upon the pooled mean difference from baseline to follow-up points showed that the stem cell transplantation group was superior to the control group with statistical significance in the neurologic deficits score (NIHSS, MD = 1.57; 95% CI, 0.64-2.51; I2 = 57 %; p = 0.001), motor function (FMA, MD = 4.23; 95% CI, 3.08-5.38; I2 = 0 %; p <0.00001), daily life ability (Barthel, MD = 8.37; 95% CI, 4.83-11.91; I2 = 63 %; p <0.00001), and functional independence (FIM, MD = 8.89; 95% CI, 4.70-13.08; I2 = 79 %; p <0.0001). Conclusions. It is suggested that the stem cell transplantation therapy for patients with brain ischemic stroke can significantly improve the neurological deficits and daily life quality, with no serious adverse events. However, higher quality and larger data studies are required for further investigation to support clinical application of stem cell transplantation.

Publication DOI:
Divisions: College of Health & Life Sciences > Aston Medical School
Additional Information: Copyright © 2016 Lukui Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Uncontrolled Keywords: Cell Biology,Molecular Biology
Publication ISSN: 1687-9678
Last Modified: 25 Mar 2024 08:18
Date Deposited: 14 Feb 2018 08:06
Full Text Link:
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2016-07-29
Accepted Date: 2016-07-28
Authors: Chen, Lukui
Zhang, Guilong
Khan, Ahsan Ali
Guo, Xiaoyuan
Gu, Yuchun (ORCID Profile 0000-0002-7558-0447)



Version: Published Version

License: Creative Commons Attribution

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