Olive oil consumption and 10-year (2002–2012) cardiovascular disease incidence: the ATTICA study


Olive oil, being rich in mono-unsaturated fatty acids and anti-inflammatory compounds, may have protective effects against cardiovascular disease (CVD). The aim of the present work was to examine the association of olive oil consumption with the 10-year CVD incidence in adults without pre-existing CVD. After controlling for various covariates, an inverse association between exclusive olive oil use and the risk of developing CVD was observed (relative risk 0.07, 95% CI: 0.01-0.66) compared to those not consuming olive oil. Further adjustment for fibrinogen plasma levels (among various inflammatory markers) showed a significant mediation effect on the previous association. These findings support exclusive olive oil consumption, a key component of the Mediterranean diet, for the primary CVD prevention, in adults without pre-existing disease. Circulating fibrinogen levels appear to play a mediating role in this relationship.

Publication DOI: https://doi.org/10.1007/s00394-017-1577-x
Divisions: College of Health & Life Sciences > Aston Medical School
College of Health & Life Sciences > Aston Medical School > Translational Medicine Research Group (TMRG)
Additional Information: © 2017 Springer Verlag GmbH, Germany. This is a post-peer-review, pre-copyedit version of an article published in European Journal of Clinical Nutrition. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00394-017-1577-x. Funding: Coca-Cola SA, ATTICA Study - Hellenic Cardiology Society and the Hellenic Atherosclerosis Society.
Uncontrolled Keywords: Cardiovascular disease,Fibrinogen,Nutrition,Olive oil,Inflammation
Publication ISSN: 1476-5640
Full Text Link:
Related URLs: http://link.spr ... 0394-017-1577-x (Publisher URL)
PURE Output Type: Article
Published Date: 2019-02-01
Published Online Date: 2017-11-09
Accepted Date: 2017-10-31
Authors: Kouli, Georgia-maria
Panagiotakos, Demosthenes B.
Kyrou, Ioannis (ORCID Profile 0000-0002-6997-3439)
Magriplis, Emanuela
Georgousopoulou, Ekavi N.
Chrysohoou, Christina
Tsigos, Constantine
Tousoulis, Dimitrios
Pitsavos, Christos



Version: Accepted Version

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