Kouli, Georgia-maria, Panagiotakos, Demosthenes B., Kyrou, Ioannis, Magriplis, Emanuela, Georgousopoulou, Ekavi N., Chrysohoou, Christina, Tsigos, Constantine, Tousoulis, Dimitrios and Pitsavos, Christos (2019). Olive oil consumption and 10-year (2002–2012) cardiovascular disease incidence: the ATTICA study. European Journal of Clinical Nutrition, 58 , 131–138.
Abstract
Olive oil, being rich in mono-unsaturated fatty acids and anti-inflammatory compounds, may have protective effects against cardiovascular disease (CVD). The aim of the present work was to examine the association of olive oil consumption with the 10-year CVD incidence in adults without pre-existing CVD. After controlling for various covariates, an inverse association between exclusive olive oil use and the risk of developing CVD was observed (relative risk 0.07, 95% CI: 0.01-0.66) compared to those not consuming olive oil. Further adjustment for fibrinogen plasma levels (among various inflammatory markers) showed a significant mediation effect on the previous association. These findings support exclusive olive oil consumption, a key component of the Mediterranean diet, for the primary CVD prevention, in adults without pre-existing disease. Circulating fibrinogen levels appear to play a mediating role in this relationship.
Publication DOI: | https://doi.org/10.1007/s00394-017-1577-x |
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Divisions: | College of Health & Life Sciences > Aston Medical School College of Health & Life Sciences > Aston Medical School > Translational Medicine Research Group (TMRG) |
Additional Information: | © 2017 Springer Verlag GmbH, Germany. This is a post-peer-review, pre-copyedit version of an article published in European Journal of Clinical Nutrition. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00394-017-1577-x. Funding: Coca-Cola SA, ATTICA Study - Hellenic Cardiology Society and the Hellenic Atherosclerosis Society. |
Uncontrolled Keywords: | Cardiovascular disease,Fibrinogen,Nutrition,Olive oil,Inflammation |
Publication ISSN: | 1476-5640 |
Last Modified: | 06 Aug 2024 07:52 |
Date Deposited: | 01 Dec 2017 10:50 |
Full Text Link: | |
Related URLs: |
http://link.spr ... 0394-017-1577-x
(Publisher URL) |
PURE Output Type: | Article |
Published Date: | 2019-02-01 |
Published Online Date: | 2017-11-09 |
Accepted Date: | 2017-10-31 |
Authors: |
Kouli, Georgia-maria
Panagiotakos, Demosthenes B. Kyrou, Ioannis ( ![]() Magriplis, Emanuela Georgousopoulou, Ekavi N. Chrysohoou, Christina Tsigos, Constantine Tousoulis, Dimitrios Pitsavos, Christos |