Non-invasive biomedical research and diagnostics enabled by innovative compact lasers


For over half a century, laser technology has undergone a technological revolution. These technologies, particularly semiconductor lasers, are employed in a myriad of fields. Optical medical diagnostics, one of the emerging areas of laser application, are on the forefront of application around the world. Optical methods of non- or minimally invasive bio-tissue investigation offer significant advantages over alternative methods, including rapid real-time measurement, non-invasiveness and high resolution (guaranteeing the safety of a patient). These advantages demonstrate the growing success of such techniques. In this review, we will outline the recent status of laser technology applied in the biomedical field, focusing on the various available approaches, particularly utilising compact semiconductor lasers. We will further consider the advancement and integration of several complimentary biophotonic techniques into single multimodal devices, the potential impact of such devices and their future applications. Based on our own studies, we will also cover the simultaneous collection of physiological data with the aid a multifunctional diagnostics system, concentrating on the optimisation of the new technology towards a clinical application. Such data is invaluable for developing algorithms capable of delivering consistent, reliable and meaningful diagnostic information, which can ultimately be employed for the early diagnosis of disease conditions in individuals from around the world.

Publication DOI:
Divisions: College of Health & Life Sciences > Aston Medical School
College of Engineering & Physical Sciences
College of Engineering & Physical Sciences > Aston Institute of Photonics Technology (AIPT)
Additional Information: © 2017, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Funding: partially supported by grant “MESO-BRAIN” (No. 713140) of Europe Union's H2020, FET-open scheme.
Uncontrolled Keywords: autofluorescence,compact laser,microcirculation,multifunctional laser diagnostics,non-invasive diagnostics,tissue oximetry,Statistical and Nonlinear Physics,Electronic, Optical and Magnetic Materials,Atomic and Molecular Physics, and Optics,Electrical and Electronic Engineering
Publication ISSN: 1873-1627
Last Modified: 15 May 2024 07:13
Date Deposited: 13 Nov 2017 12:15
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Review article
Published Date: 2017-10-12
Accepted Date: 2017-10-12
Authors: Litvinova, Karina S. (ORCID Profile 0000-0003-1110-8589)
Rafailov, Ilya E.
Dunaev, Andrey V.
Sokolovski, Sergei G. (ORCID Profile 0000-0001-7445-7204)
Rafailov, Edik U. (ORCID Profile 0000-0002-4152-0120)

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