Development and Characterization of Gallium-Doped Bioactive Glasses for Potential Bone Cancer Applications

Abstract

In this study, we have developed a series of novel gallium oxide doped bioactive glasses to specifically target osteosarcoma cells while aiding new bone formation. The results show that osteosarcoma (Saos-2) cell death is induced through the addition of gallium oxide. Relative to the gallium-free control glass (0% Ga) glasses containing 1, 2, and 3% Ga decreased Saos-2 cell viability in a dose dependent manner. After 72 h in media preconditioned with 3% Ga Saos-2 cell viability was reduced by over 50%. Corresponding studies undertaken on primary normal human osteoblast cells (NHOst) demonstrated no adverse effects to the gallium containing glasses. Hydroxyapatite formation was observed for all glasses when exposed to simulated body fluid.

Publication DOI: https://doi.org/10.1021/acsbiomaterials.7b00283
Divisions: College of Health & Life Sciences > School of Biosciences
College of Engineering & Physical Sciences > School of Informatics and Digital Engineering > Electrical and Electronic Engineering
College of Engineering & Physical Sciences
College of Engineering & Physical Sciences > School of Infrastructure and Sustainable Engineering > Chemical Engineering & Applied Chemistry
College of Engineering & Physical Sciences > Aston Institute of Materials Research (AIMR)
Additional Information: Copyright © 2017 American Chemical Society. This is the accepted author manuscript. Funding: Osteosarcoma UK.
Uncontrolled Keywords: apatite; bioactive glass; bone; cancer; gallium; sarcoma
Full Text Link:
Related URLs: http://pubs.acs ... terials.7b00283 (Publisher URL)
PURE Output Type: Article
Published Date: 2017-12-11
Published Online Date: 2017-09-22
Accepted Date: 2017-09-22
Authors: Rana, Karan S.
Souza, Lucas Pereira De (ORCID Profile 0000-0002-0188-5168)
Isaacs, Mark A.
Raja, Farah N. S.
Morrell, Alexander P.
Martin, Richard A (ORCID Profile 0000-0002-6013-2334)

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