Multimodal optical measurement for study of lower limb tissue viability in patients with diabetes mellitus


According to the International Diabetes Federation, the challenge of early stage diagnosis and treatment effectiveness monitoring in diabetes is currently one of the highest priorities in modern healthcare. The potential of combined measurements of skin fluorescence and blood perfusion by the laser Doppler flowmetry method in diagnostics of low limb diabetes complications was evaluated. Using Monte Carlo probabilistic modeling, the diagnostic volume and depth of the diagnosis were evaluated. The experimental study involved 76 patients with type 2 diabetes mellitus. These patients were divided into two groups depending on the degree of complications. The control group consisted of 48 healthy volunteers. The local thermal stimulation was selected as a stimulus on the blood microcirculation system. The experimental studies have shown that diabetic patients have elevated values of normalized fluorescence amplitudes, as well as a lower perfusion response to local heating. In the group of people with diabetes with trophic ulcers, these parameters also significantly differ from the control and diabetes only groups. Thus, the intensity of skin fluorescence and level of tissue blood perfusion can act as markers for various degrees of complications from the beginning of diabetes to the formation of trophic ulcers.

Publication DOI:
Divisions: College of Engineering & Physical Sciences
College of Health & Life Sciences > Aston Medical School
College of Engineering & Physical Sciences > Aston Institute of Photonics Technology (AIPT)
Additional Information: Viktor V. Dremin, Evgeny A. Zherebtsov, Victor V. Sidorov, Alexander I. Krupatkin, Irina N. Makovik, Angelina I. Zherebtsova, Elena V. Zharkikh, Elena V. Potapova, Andrey V. Dunaev, Alexander A. Doronin, Alexander V. Bykov, Ilya E. Rafailov, Karina S. Litvinova, Sergei G. Sokolovski, Edik U. Rafailov, "Multimodal optical measurement for study of lower limb tissue viability in patients with diabetes mellitus," Journal of Biomedical Optics 22(8), 085003 (19 August 2017). Copyright 2017. Society of Photo-Optical Instrumentation Engineers (SPIE). One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.
Uncontrolled Keywords: advanced glycation end products,diabetes mellitus,diagnostic volume,fluorescence spectroscopy,laser Doppler flowmetry,metabolism,mitochondrial function,Electronic, Optical and Magnetic Materials,Atomic and Molecular Physics, and Optics,Biomaterials,Biomedical Engineering
Publication ISSN: 1560-2281
Last Modified: 20 May 2024 07:20
Date Deposited: 28 Sep 2017 09:05
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2017-08-19
Accepted Date: 2017-07-21
Authors: Dremin, Viktor V.
Zherebtsov, Evgeny A. (ORCID Profile 0000-0002-3635-1430)
Sidorov, Victor V.
Krupatkin, Alexander I.
Makovik, Irina N.
Zherebtsova, Angelina I.
Zharkikh, Elena V.
Potapova, Elena V.
Dunaev, Andrey V.
Doronin, Alexander A.
Bykov, Alexander V.
Rafailov, Ilya E.
Litvinova, Karina S. (ORCID Profile 0000-0003-1110-8589)
Sokolovski, Sergei G. (ORCID Profile 0000-0001-7445-7204)
Rafailov, Edik U. (ORCID Profile 0000-0002-4152-0120)



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