Visceral adiposity index and 10-year cardiovascular disease incidence:the ATTICA study


Background and aims: Visceral adiposity index (VAI) has been proposed as a marker of visceral adipose tissue accumulation/dysfunction. Our aim was to evaluate potential associations between the VAI and the 10-year cardiovascular disease (CVD) incidence. Methods and results: During 2001-2002, 3042 Greek adults (1514 men; age: ≥18 years) without previous CVD were recruited into the ATTICA study, whilst the 10-year study follow-up was performed in 2011-2012, recording the fatal/non-fatal CVD incidence in 2020 (1010 men) participants. The baseline VAI scores for these participants were calculated based on anthropometric and lipid variables, while VAI tertiles were extracted for further analyses. During the study follow-up a total of 317 CVD events (15.7%) were observed. At baseline, the participants' age and the prevalence of hypertension, diabetes, hypercholesterolemia and metabolic syndrome increased significantly across the VAI tertiles. After adjusting for multiple confounders, VAI exhibited a significantly independent positive association with the 10-year CVD incidence (OR = 1.05, 95%CI: 1.01, 1.10), whereas the association of the body mass index (HR = 1.03, 95%CI: 0.99, 1.08), or the waist circumference (HR = 1.01, 95%CI: 0.99, 1.02) was less prominent. Sex-specific analysis further showed that VAI remained significantly predictive of CVD in men alone (HR = 1.06, 95%CI: 1.00, 1.11) but not in women (HR = 1.06, 95%CI: 0.96, 1.10). Conclusions: Our findings show for the first time in a large-sample, long-term, prospective study in Europe that the VAI is independently associated with elevated 10-year CVD risk, particularly in men. This suggests that the VAI may be utilized as an additional indicator of long-term CVD risk for Caucasian/Mediterranean men without previous CVD.

Publication DOI:
Divisions: College of Health & Life Sciences > Aston Medical School
Additional Information: *
Uncontrolled Keywords: abdominal visceral fat,cardiovascular diseases,visceral adipose tissue,visceral adiposity index,visceral fat,Medicine (miscellaneous),Endocrinology, Diabetes and Metabolism,Nutrition and Dietetics,Cardiology and Cardiovascular Medicine
Publication ISSN: 1590-3729
Last Modified: 10 Jun 2024 07:22
Date Deposited: 20 Sep 2017 10:15
Full Text Link:
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2017-10
Published Online Date: 2017-07-08
Accepted Date: 2017-06-26
Authors: Kouli, G.-M.
Panagiotakos, D.B.
Kyrou, I. (ORCID Profile 0000-0002-6997-3439)
Georgousopoulou, E.N.
Chrysohoou, C.
Tsigos, C.
Tousoulis, D.
Pitsavos, C.

Export / Share Citation


Additional statistics for this record