Functionalised solids delivering bioactive nitric oxide gas for therapeutic applications


It is well established that nitric oxide is an effective vasodilative, antibacterial and tumoricidal agent, however its targeted delivery in a controllable manner is challenging but necessary for successful therapeutic applications. In recent years a few new methods have been developed, based on the formation of N-diazeniumdiolates, S-nitrosothiols and metal [sbnd]NO coordination bonds in material structures. The typical delivery materials include nanoporous materials (such as zeolites and metal organic frameworks), silicate particles and polymers containing amine and thiol functional groups. These materials are of promising potential for delivering controllable doses of bioactive NO gas to meet the unmet therapeutic needs in the future. This review summarises these delivery materials and relevant biological assessments. Further improvement of current methods and new design of NO donors are still required in order to address the issues on NO storage and its release profile in matching with the clinical requirements.

Publication DOI:
Divisions: College of Engineering & Physical Sciences > School of Infrastructure and Sustainable Engineering > Chemical Engineering & Applied Chemistry
College of Engineering & Physical Sciences > Aston Institute of Materials Research (AIMR)
College of Engineering & Physical Sciences > Energy and Bioproducts Research Institute (EBRI)
Additional Information: © 2017, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Funding: EPSRC (EP/M027295/1).
Uncontrolled Keywords: antomicrobials,drug delivery,metal organic framework,nitric oxide,nitric oxide biological function,zeolite,Materials Science(all),Mechanics of Materials,Materials Chemistry
Publication ISSN: 2352-4928
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2017-09
Published Online Date: 2017-07-31
Accepted Date: 2017-07-28
Authors: Gregg, Sharon T.
Yuan, Qingchun (ORCID Profile 0000-0001-5982-3819)
Morris, Russell E.
Xiao, Bo

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