Wigby, Stuart, Slack, Cathy, Grönke, Sebastian, Martinez, Pedro, Calboli, Federico C.F., Chapman, Tracey and Partridge, Linda (2011). Insulin signalling regulates remating in female drosophila. Proceeding of the Royal Society: Series B, 278 (1704), pp. 424-431.
Abstract
Mating rate is a major determinant of female lifespan and fitness, and is predicted to optimize at an intermediate level, beyond which superfluous matings are costly. In female Drosophila melanogaster, nutrition is a key regulator of mating rate but the underlying mechanism is unknown. The evolutionarily conserved insulin/insulin-like growth factor-like signalling (IIS) pathway is responsive to nutrition, and regulates development, metabolism, stress resistance, fecundity and lifespan. Here we show that inhibition of IIS, by ablation of Drosophila insulin-like peptide (DILP)-producing median neurosecretory cells, knockout of dilp2, dilp3 or dilp5 genes, expression of a dominant-negative DILP-receptor (InR) transgene or knockout of Lnk, results in reduced female remating rates. IIS-mediated regulation of female remating can occur independent of virgin receptivity, developmental defects, reduced body size or fecundity, and the receipt of the female receptivity-inhibiting male sex peptide. Our results provide a likely mechanism by which females match remating rates to the perceived nutritional environment. The findings suggest that longevity-mediating genes could often have pleiotropic effects on remating rate. However, overexpression of the IIS-regulated transcription factor dFOXO in the fat body-which extends lifespan- does not affect remating rate. Thus, long life and reduced remating are not obligatorily coupled.
Publication DOI: | https://doi.org/10.1098/rspb.2010.1390 |
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Divisions: | College of Health & Life Sciences College of Health & Life Sciences > School of Biosciences > Cell & Tissue Biomedical Research |
Additional Information: | This journal is © 2010 The Royal Society This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Uncontrolled Keywords: | drosophila melanogaster,fitness,mating and reproduction,nutrition,sexual selection,trade-off,General Medicine,General Immunology and Microbiology,General Biochemistry,Genetics and Molecular Biology,General Environmental Science,General Agricultural and Biological Sciences |
Publication ISSN: | 1471-2954 |
Last Modified: | 29 Nov 2024 08:07 |
Date Deposited: | 03 May 2017 12:05 |
Full Text Link: | |
Related URLs: |
http://www.scop ... tnerID=8YFLogxK
(Scopus URL) |
PURE Output Type: | Article |
Published Date: | 2011-02-07 |
Published Online Date: | 2010-12-22 |
Accepted Date: | 2010-07-30 |
Authors: |
Wigby, Stuart
Slack, Cathy ( 0000-0002-7949-4079) Grönke, Sebastian Martinez, Pedro Calboli, Federico C.F. Chapman, Tracey Partridge, Linda |