Laminar degeneration of frontal and temporal cortex in Parkinson disease dementia


To investigate cortical laminar degeneration in Parkinson’s disease (PD) with dementia (PDD). Changes in density of α-synuclein-immunoreactive Lewy bodies (LB), Lewy neurites (LN), and Lewy grains (LG) together with surviving neurons, abnormally enlarged neurons (EN), vacuoles, and glial cell nuclei were measured across cortical laminae of frontal and temporal cortex in fifteen cases of PDD using quantitative methods and polynomial curve-fitting. Most frequently, LB and LN were distributed across all laminae, while LG were distributed in upper cortical laminae. Low densities of EN were present in most cases distributed across all cortical laminae. Densities of vacuoles and glia were greatest in upper and lower cortical laminae, respectively. In most gyri, there were no spatial correlations between the densities of LB, LN, and LG. Cortical degeneration of frontal and temporal lobes in PDD affects all cortical laminae. Laminar distributions may result from the spread of α-synuclein pathology from subcortical regions and subsequent spread via the cortico-cortical pathways. This spread may be a major factor in the development of dementia in PD.

Publication DOI:
Divisions: College of Health & Life Sciences > School of Optometry > Optometry
College of Health & Life Sciences > School of Optometry > Optometry & Vision Science Research Group (OVSRG)
College of Health & Life Sciences > School of Optometry > Vision, Hearing and Language
College of Health & Life Sciences > Clinical and Systems Neuroscience
Additional Information: The final publication is available at Springer via
Uncontrolled Keywords: cortical degeneration,laminar distribution,Lewy body,Parkinson’s disease dementia (PDD),polynomial curve fitting,synucleinopathy,Dermatology,Clinical Neurology,Psychiatry and Mental health
Publication ISSN: 1590-3478
Full Text Link:
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2017-04-01
Published Online Date: 2017-02-08
Accepted Date: 2017-02-08
Authors: Armstrong, Richard A. (ORCID Profile 0000-0002-5046-3199)



Version: Accepted Version

| Preview

Export / Share Citation


Additional statistics for this record