Wood, Amanda G, Chen, Jian, Moran, Christopher, Phan, Thanh, Beare, Richard, Cooper, Kimberley, Litras, Stacey and Srikanth, Velandai (2016). Brain activation during memory encoding in type 2 diabetes mellitus:a discordant twin pair study. Experimental Diabetes Research, 2016 ,
Abstract
Type 2 diabetes mellitus increases the risk of dementia and neuronal dysfunction may occur years before perceptible cognitive decline. We aimed to study the impact of type 2 diabetes on brain activation during memory encoding in middle-aged people, controlling for age, sex, genes, and early-shared environment. Twenty-two twin pairs discordant for type 2 diabetes mellitus (mean age 60.9 years) without neurological disease were recruited from the Australian Twin Registry (ATR) and underwent functional magnetic resonance imaging (fMRI) during a memory encoding task, cognitive tests, and structural MRI. Type 2 diabetes was associated with significantly reduced activation in left hemisphere temporoparietal regions including angular gyrus, supramarginal gyrus, and middle temporal gyrus and significantly increased activation in bilateral posteriorly distributed regions. These findings were present in the absence of within-pair differences in standard cognitive test scores, brain volumes, or vascular lesion load. Differences in activation were more pronounced among monozygotic (MZ) pairs, with MZ individuals with diabetes also displaying greater frontal activation. These results provide evidence for preclinical memory-related neuronal dysfunction in type 2 diabetes. They support the search for modifiable later-life environmental factors or epigenetic mechanisms linking type 2 diabetes and cognitive decline.
Publication DOI: | https://doi.org/10.1155/2016/3978428 |
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Divisions: | College of Health & Life Sciences |
Additional Information: | © 2016 Amanda G. Wood et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Uncontrolled Keywords: | Journal Article |
Publication ISSN: | 1687-5303 |
Last Modified: | 11 Oct 2024 07:15 |
Date Deposited: | 25 Jan 2017 15:45 | PURE Output Type: | Article |
Published Date: | 2016-04-30 |
Accepted Date: | 2016-04-17 |
Submitted Date: | 2015-12-29 |
Authors: |
Wood, Amanda G
(
0000-0002-1537-6858)
Chen, Jian Moran, Christopher Phan, Thanh Beare, Richard Cooper, Kimberley Litras, Stacey Srikanth, Velandai |