Altered cortical thickness following prenatal sodium valproate exposure

Abstract

Prenatal exposure to sodium valproate (VPA) is associated with neurodevelopmental impairments. Cortical thickness was measured in 16 children exposed prenatally to VPA and 16 controls. We found increased left inferior frontal gyrus (IFG; BA45) and left pericalcarine sulcus (BA18) thickness, an association between VPA dose and right IFG thickness, and a close relationship between verbal skills and left IFG thickness. A significant interaction between group and hemispheric IFG thickness showed absence of the normal asymmetry in the IFG region of VPA-exposed children. These data provide preliminary insights into the putative neural basis of difficulties experienced by some VPA-exposed children.

Publication DOI: https://doi.org/10.1002/acn3.74
Divisions: College of Health & Life Sciences
Additional Information: © 2014 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Publication ISSN: 2328-9503
Last Modified: 30 Sep 2024 11:02
Date Deposited: 24 Jan 2017 15:20
PURE Output Type: Article
Published Date: 2014-07-03
Accepted Date: 2014-05-20
Submitted Date: 2014-05-03
Authors: Wood, Amanda G. (ORCID Profile 0000-0002-1537-6858)
Chen, Jian
Barton, Sarah
Nadebaum, Caroline
Anderson, Vicki A.
Catroppa, Cathy
Reutens, David C.
O'Brien, Terence J.
Vajda, Frank

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