CCR5 is a suppressor for cortical plasticity and hippocampal learning and memory


Although the role of CCR5 in immunity and in HIV infection has been studied widely, its role in neuronal plasticity, learning and memory is not understood. Here, we report that decreasing the function of CCR5 increases MAPK/CREB signaling, long-term potentiation (LTP), and hippocampus-dependent memory in mice, while neuronal CCR5 overexpression caused memory deficits. Decreasing CCR5 function in mouse barrel cortex also resulted in enhanced spike timing dependent plasticity and consequently, dramatically accelerated experience-dependent plasticity. These results suggest that CCR5 is a powerful suppressor for plasticity and memory, and CCR5 over-activation by viral proteins may contribute to HIV-associated cognitive deficits. Consistent with this hypothesis, the HIV V3 peptide caused LTP, signaling and memory deficits that were prevented by Ccr5 knockout or knockdown. Overall, our results demonstrate that CCR5 plays an important role in neuroplasticity, learning and memory, and indicate that CCR5 has a role in the cognitive deficits caused by HIV.

Publication DOI:
Divisions: College of Health & Life Sciences
Uncontrolled Keywords: neuroscience,plasticity,HIV,dementia,Neuroscience(all),Medicine(all),Immunology and Microbiology(all),Biochemistry, Genetics and Molecular Biology(all)
Publication ISSN: 2050-084X
Last Modified: 20 May 2024 07:17
Date Deposited: 17 Jan 2017 09:00
Full Text Link:
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2016-12-20
Accepted Date: 2016-12-19
Submitted Date: 2016-08-26
Authors: Zhou, Miou
Greenhill, Stuart (ORCID Profile 0000-0002-5038-5258)
Huang, Shan
Silva, Tawnie K.
Sano, Yoshitake
Wu, Shumin
Cai, Ying
Nagaoka, Yoshiko
Sehgal, Megha
Cai, Denise J.
Lee, Yong-Seok
Fox, Kevin
Silva, Alcino J.



Version: Published Version

License: Creative Commons Attribution

Export / Share Citation


Additional statistics for this record