Association of depression and anxiety status with 10-year cardiovascular disease incidence among apparently healthy Greek adults:the ATTICA study


Background: Chronic stress frequently manifests with anxiety and/or depressive symptomatology and may have detrimental cardiometabolic effects over time. As such, recognising the potential links between stress-related psychological disorders and cardiovascular disease (CVD) is becoming increasingly important in cardiovascular epidemiology research. The primary aim of this study was to explore prospectively potential associations between clinically relevant depressive symptomatology and anxiety levels and the 10-year CVD incidence among apparently healthy Greek adults. Design: A population-based, health and nutrition prospective survey. Methods: In the context of the ATTICA Study (2002–2012), 853 adult participants without previous CVD history (453 men (45 ± 13 years) and 400 women (44 ± 18 years)) underwent psychological evaluations through validated, self-reporting depression and anxiety questionnaires. Results: After adjustment for multiple established CVD risk factors, both reported depression and anxiety levels were positively and independently associated with the 10-year CVD incidence, with depression markedly increasing the CVD risk by approximately fourfold (adjusted odds ratio (95% confidence interval) 3.6 (1.3, 11) for depression status; 1.03 (1.0, 1.1) for anxiety levels). Conclusions: Our findings indicate that standardised psychological assessments focusing on depression and anxiety should be considered as an additional and distinct aspect in the context of CVD preventive strategies that are designed and implemented by health authorities at the general population level.

Publication DOI:
Divisions: College of Health & Life Sciences > Aston Medical School
Uncontrolled Keywords: anxiety,ATTICA Study,cardiovascular disease,CVD risk factors,depression,Epidemiology,Cardiology and Cardiovascular Medicine
Publication ISSN: 2047-4881
Full Text Link:
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2017-01
Published Online Date: 2016-09-26
Accepted Date: 2016-09-01
Authors: Kyrou, Ioannis (ORCID Profile 0000-0002-6997-3439)
Kollia, Natasa
Panagiotakos, Demosthenes
Georgousopoulou, Ekavi
Chrysohoou, Christina
Tsigos, Constantine
Randeva, Harpal S.
Yannakoulia, Mary
Stefanadis, Christodoulos
Papageorgiou, Charalabos
Pitsavos, Christos
, for the ATTICA Study investigators



Version: Accepted Version

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