Behavioral and molecular genetics of reading-related AM and FM detection thresholds


Auditory detection thresholds for certain frequencies of both amplitude modulated (AM) and frequency modulated (FM) dynamic auditory stimuli are associated with reading in typically developing and dyslexic readers. We present the first behavioral and molecular genetic characterization of these two auditory traits. Two extant extended family datasets were given reading tasks and psychoacoustic tasks to determine FM 2 Hz and AM 20 Hz sensitivity thresholds. Univariate heritabilities were significant for both AM (h2 = 0.20) and FM (h2 = 0.29). Bayesian posterior probability of linkage (PPL) analysis found loci for AM (12q, PPL = 81 %) and FM (10p, PPL = 32 %; 20q, PPL = 65 %). Bivariate heritability analyses revealed that FM is genetically correlated with reading, while AM was not. Bivariate PPL analysis indicates that FM loci (10p, 20q) are not also associated with reading.

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Divisions: College of Health & Life Sciences > School of Psychology
College of Health & Life Sciences
College of Health & Life Sciences > Clinical and Systems Neuroscience
College of Health & Life Sciences > School of Optometry > Vision, Hearing and Language
College of Health & Life Sciences > Aston Institute of Health & Neurodevelopment (AIHN)
Additional Information: The final publication is available at Springer via
Uncontrolled Keywords: dynamic auditory sensitivity,AM sensitivity,FM sensitivity,reading,language,heritability,Ecology, Evolution, Behavior and Systematics,Genetics,Genetics(clinical)
Publication ISSN: 1573-3297
Last Modified: 26 Feb 2024 08:17
Date Deposited: 21 Nov 2016 11:00
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2017-03
Published Online Date: 2016-11-09
Accepted Date: 2016-09-28
Submitted Date: 2015-07-15
Authors: Bruni, Matthew
Flax, Judy F.
Buyske, Steven
Shindhelm, Amber D.
Witton, Caroline (ORCID Profile 0000-0002-5610-4234)
Brzustowicz, Linda M.
Bartlett, Christopher W.



Version: Accepted Version

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