A randomized double-blind placebo-controlled crossover trial of sodium nitrate in patients with stable angina INAS


In an aging western population, a significant number of patients continue to suffer from angina once all revascularization and optimal medical treatment options are exhausted. Under experimental conditions, oral supplementation with inorganic nitrate was shown to exhibit a blood pressure-lowering effect, and has also been shown to promote angiogenesis, improve endothelial dysfunction and mitochondrial efficiency in skeletal muscle. It is unknown whether similar changes occur in cardiac muscle. In the current study, we investigate whether oral sodium nitrate treatment will improve myocardial ischemia in patients with stable angina.

Publication DOI: https://doi.org/10.2217/fca-2016-0026
Divisions: College of Health & Life Sciences > Aston Medical School
Uncontrolled Keywords: angina,Inorganic nitrate,randomized controlled trial,Molecular Medicine,Cardiology and Cardiovascular Medicine
Publication ISSN: 1744-8298
Last Modified: 16 Apr 2024 07:12
Date Deposited: 14 Nov 2016 11:25
Full Text Link:
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
http://www.futu ... 7/fca-2016-0026 (Publisher URL)
PURE Output Type: Article
Published Date: 2016-11
Published Online Date: 2016-10-12
Accepted Date: 2016-04-01
Authors: Schwarz, Konstantin
Singh, Satnam
Parasuraman, Satish Kumar
Bruce, Maggie
Shepstone, Lee
Feelisch, Martin
Minnion, Magdalena
Ahmad, Shakil (ORCID Profile 0000-0002-9294-0475)
Horowitz, John
Dawson, Dana K.
Frenneaux, Michael P.



Version: Accepted Version

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