Long-term efficacy of orthokeratology contact lens wear in controlling the progression of childhood myopia


Purpose: The primary outcome of this study is to compare the axial length growth of white European myopic children wearing orthokeratology contact lenses (OK) to a control group (CT) over a 7-year period. Methods: Subjects 6–12 years of age with myopia −0.75 to −4.00DS and astigmatism ≤1.00DC were prospectively allocated OK or distance single-vision spectacles (SV) correction. Measurements of axial length (Zeiss IOLMaster), corneal topography, and cycloplegic refraction were taken at 6-month intervals over a 2-year period. Subjects were invited to return to the clinic approximately 5 years later (i.e., 7 years after the beginning of the study) for assessment of their ocular refractive and biometric components. The CT consisted of 4 SV and 12 subjects who switched from SV to soft contact lens wear after the initial 2 years of SV lens wear. Changes in axial length relative to baseline over a 7-year period were compared between groups. Results: Fourteen and 16 subjects from the OK and CT groups, respectively, were examined 6.7 ± 0.5 years after the beginning of the study. Statistically significant changes in the axial length were found over time and between groups (both p <0.001), but not for the time*group interaction (p = 0.125). The change in the axial length for the OK group was 22% (p = 0.328), 42% (p = 0.007), 40% (p = 0.020), 41% (p = 0.013), and 33% (p = 0.062) lower than the CT group following 6, 12, 18, 24, and 84 months of lens wear, respectively. Conclusion: A trend toward a reduction in the rate of axial elongation of the order of 33% was found in the OK group in comparison to the CT group following 7 years of lens wear.

Publication DOI: https://doi.org/10.1080/02713683.2016.1221979
Divisions: College of Health & Life Sciences > School of Optometry > Optometry
College of Health & Life Sciences > School of Optometry > Optometry & Vision Science Research Group (OVSRG)
College of Health & Life Sciences
College of Health & Life Sciences > School of Optometry > Vision, Hearing and Language
Additional Information: This is an Accepted Manuscript of an article published by Taylor & Francis in Current Eye Research on 21/10/16, available online: http://www.tandfonline.com/10.1080/02713683.2016.1221979
Uncontrolled Keywords: axial length,long-term efficacy,myopia control,myopia progression,orthokeratology,Ophthalmology,Sensory Systems,Cellular and Molecular Neuroscience
Publication ISSN: 1460-2202
Full Text Link:
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
http://www.tand ... 83.2016.1221979 (Publisher URL)
PURE Output Type: Article
Published Date: 2017
Published Online Date: 2016-10-21
Accepted Date: 2016-10-21
Submitted Date: 2016-05-20
Authors: Santodomingo-Rubido, Jacinto
Villa-Collar, César
Gilmartin, Bernard
Gutiérrez-Ortega, Ramón
Sugimoto, Keiji



Version: Accepted Version

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