Towards a 21st-century roadmap for biomedical research and drug discovery:consensus report and recommendations


Decades of costly failures in translating drug candidates from preclinical disease models to human therapeutic use warrant reconsideration of the priority placed on animal models in biomedical research. Following an international workshop attended by experts from academia, government institutions, research funding bodies, and the corporate and nongovernmental organisation (NGO) sectors, in this consensus report, we analyse, as case studies, five disease areas with major unmet needs for new treatments. In view of the scientifically driven transition towards a human pathway-based paradigm in toxicology, a similar paradigm shift appears to be justified in biomedical research. There is a pressing need for an approach that strategically implements advanced, human biology-based models and tools to understand disease pathways at multiple biological scales. We present recommendations to help achieve this.

Publication DOI:
Divisions: College of Health & Life Sciences > School of Biosciences
College of Health & Life Sciences
College of Health & Life Sciences > Chronic and Communicable Conditions
College of Health & Life Sciences > School of Biosciences > Cell & Tissue Biomedical Research
Additional Information: © 2016, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Uncontrolled Keywords: biomedical research,research funding,adverse outcome pathways,21st-century roadmap,human-specific models,human disease pathways,Pharmacology,Drug Discovery
Publication ISSN: 1878-5832
Last Modified: 15 Apr 2024 07:19
Date Deposited: 02 Nov 2016 12:25
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Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2017-02
Published Online Date: 2016-10-29
Accepted Date: 2016-10-24
Submitted Date: 2016-07-26
Authors: Langley, Gillian R.
Adcock, Ian M.
Busquet, François
Crofton, Kevin M.
Csernok, Elena
Giese, Christoph
Heinonen, Tuula
Herrmann, Kathrin
Hofmann-Apitius, Martin
Landesmann, Brigitte
Marshall, Lindsay J. (ORCID Profile 0000-0001-7281-7974)
Mcivor, Emily
Muotri, Alysson R.
Noor, Fozia
Schutte, Katrin
Seidle, Troy
van de Stolpe, Anja
van Esch, Hilde
Willett, Catherine
Woszczek, Grzegorz

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