Langley, Gillian R., Adcock, Ian M., Busquet, François, Crofton, Kevin M., Csernok, Elena, Giese, Christoph, Heinonen, Tuula, Herrmann, Kathrin, Hofmann-Apitius, Martin, Landesmann, Brigitte, Marshall, Lindsay J., Mcivor, Emily, Muotri, Alysson R., Noor, Fozia, Schutte, Katrin, Seidle, Troy, van de Stolpe, Anja, van Esch, Hilde, Willett, Catherine and Woszczek, Grzegorz (2017). Towards a 21st-century roadmap for biomedical research and drug discovery:consensus report and recommendations. Drug Discovery Today, 22 (2), pp. 327-339.
Abstract
Decades of costly failures in translating drug candidates from preclinical disease models to human therapeutic use warrant reconsideration of the priority placed on animal models in biomedical research. Following an international workshop attended by experts from academia, government institutions, research funding bodies, and the corporate and nongovernmental organisation (NGO) sectors, in this consensus report, we analyse, as case studies, five disease areas with major unmet needs for new treatments. In view of the scientifically driven transition towards a human pathway-based paradigm in toxicology, a similar paradigm shift appears to be justified in biomedical research. There is a pressing need for an approach that strategically implements advanced, human biology-based models and tools to understand disease pathways at multiple biological scales. We present recommendations to help achieve this.
Publication DOI: | https://doi.org/10.1016/j.drudis.2016.10.011 |
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Divisions: | College of Health & Life Sciences > School of Biosciences College of Health & Life Sciences College of Health & Life Sciences > Chronic and Communicable Conditions College of Health & Life Sciences > School of Biosciences > Cell & Tissue Biomedical Research |
Additional Information: | © 2016, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
Uncontrolled Keywords: | biomedical research,research funding,adverse outcome pathways,21st-century roadmap,human-specific models,human disease pathways,Pharmacology,Drug Discovery |
Publication ISSN: | 1878-5832 |
Last Modified: | 30 Sep 2024 10:58 |
Date Deposited: | 02 Nov 2016 12:25 |
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Related URLs: |
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PURE Output Type: | Article |
Published Date: | 2017-02 |
Published Online Date: | 2016-10-29 |
Accepted Date: | 2016-10-24 |
Submitted Date: | 2016-07-26 |
Authors: |
Langley, Gillian R.
Adcock, Ian M. Busquet, François Crofton, Kevin M. Csernok, Elena Giese, Christoph Heinonen, Tuula Herrmann, Kathrin Hofmann-Apitius, Martin Landesmann, Brigitte Marshall, Lindsay J. ( 0000-0001-7281-7974) Mcivor, Emily Muotri, Alysson R. Noor, Fozia Schutte, Katrin Seidle, Troy van de Stolpe, Anja van Esch, Hilde Willett, Catherine Woszczek, Grzegorz |
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